To study and compare the analgesic effect of Dexmedetomidine with Levobupivacaine, Ropivacaine and Bupivacaine under spinal anesthesia.

Phase 3

• Conditions: Health Condition 1: O- Medical and Surgical

• Registration Number: CTRI/2023/06/054099
• Lead Sponsor: Department of Anaesthesia and Critical Care

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 June 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Consent from patients and ASA grading I-II posted for lower abdominal and lower limb surgical procedures planned under subarachnoid block.

Exclusion Criteria

Non consenting as well pregnant patients, any spinal deformities, infection at the site,uncontrolled co-existing systemic and metabolic diseases, history of alcohol abuse, known sensivity to any LAAs and dexmedetomidine shall be excluded from the study , patients on beta blockers and sinus bradycardia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Onset, peak & level of Sensory block ( in seconds) <br/ ><br>Onset, peak & level of Motor block ( in seconds) <br/ ><br>Total duration of Analgesia (in minutes) <br/ ><br>Time for rescue Analgesia (in minutes) <br/ ><br>Total doses & amount (in mg ) of rescue analgesia <br/ ><br>Haemodynamic parameters ( HR, PR,SBP,DBP, MAP, RR, SPO2)Timepoint: Onset, peak & level of Sensory block ( in seconds) <br/ ><br>Onset, peak & level of Motor block ( in seconds) <br/ ><br>Total duration of Analgesia (in minutes) <br/ ><br>Time for rescue Analgesia (in minutes) <br/ ><br>Total doses & amount (in mg ) of rescue analgesia <br/ ><br>Haemodynamic parameters ( HR, PR,SBP,DBP, MAP, RR, SPO2) every 3 minutes till block achieved then every 10 minutes

Secondary Outcome Measures

Name	Time	Method
To find out side effects & complications, if any.Timepoint: VAS monitoring continued every 6 hours for next 24 hours. <br/ ><br>V0 :- VAS at the time of giving spinal (T0) <br/ ><br>V1:- peak of sensory block (T3) <br/ ><br>V2:- 2 segment regression (T5) <br/ ><br>V3:- injection of rescue analgesia (T6) <br/ ><br>V4:- at the time of shifting to the ward (T7) <br/ ><br>V5,V6,V7 & V8 will be the measurement of VAS for next 24 hours. <br/ ><br>After 24 hours, patient will be shifted to systemic analgesics & released from the study.