Precision Pain Management for Major Abdominal Surgery in Colorectal Surgery
Not Applicable
Terminated
- Conditions
- Colorectal CancerDiverticular DiseaseCrohn DiseaseUlcerative Colitis
- Registration Number
- NCT03455751
- Lead Sponsor
- The Cleveland Clinic
- Brief Summary
The primary objectives of this study are to evaluate the potential for preoperative pharmacogenomics (PGx) testing to positively influence postoperative opioid use through visual analog scale (VAS) guided administration of narcotic equivalent and lower pain scores as measured by OBAS in patients undergoing major abdominal surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Subject capable of giving consent
- Age 18-80
- Scheduled for open colorectal resection at Cleveland Clinic main campus (with preoperative appointment scheduled at least five days before date of surgery)
Exclusion Criteria
- Patient does not speak English
- Patient with substance-use disorder (including alcohol)
- Patient diagnosed with major depression
- Patient currently taking opioids
- Previous long-term opioid use (> 3 months)
- Previous opioid use with a dose of >100 milligram morphine equivalent (MME)
- Patient has pain-related disorder (e.g. fibromyalgia, sympathetic dystrophy, etc.)
- Documented allergy to pain medication
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Post-operative opioid use Post-op day 1 Post-operative opioid use through visual analog scale guided administration of narcotic equivalent
Overall Benefit of Analgesia Score (OBAS) Post-op day 1
- Secondary Outcome Measures
Name Time Method Length of stay 30 days Readmission rate 30 days Functional status 4 weeks and 3 months Assessed through Duke Activity Status Index (DASI)
Trial Locations
- Locations (1)
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic🇺🇸Cleveland, Ohio, United States