Basic Research on Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow in a Humane Experimental Headache Model
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Headache scores
研究概览
简要总结
In this study the investigators will research the hypothesis that the gas carbon monoxide induces headache and increases the blood flow velocity in the middle cerebral artery.
详细描述
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.
With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Aged 18-50
- •50-100 kg
排除标准
- •Tension type headache more than once/month
- •Other primary headaches
- •Daily medication except contraceptives
- •Drug taken within 4 times the halflife for the specific drug except contraceptives
- •Pregnant or lactating women
- •Exposure to radiation within the last year
- •Headache within the last 24 hours before start of trial
- •Hypertension
- •Hypotension
- •Respiratory or cardiac disease
- •Primary relatives with current or previous migraine
研究组 & 干预措施
placebo
Atmospheric air
干预措施: Placebo (Other)
carbon monoxide
Inhalation of carbon monoxide up to a carboxyhemoglobin concentration of 12% and 22%.
干预措施: Carbon monoxide (Other)
结局指标
主要结局
Headache scores
时间窗: 12 h
Comparison between carbon monoxide and placebo (atmospheric air)
次要结局
- Blood flow velocity(0-180 min after inhalation)
- Artery circumference(0-180 min)
- Facial blood flow(0-180 min)
研究者
Nanna Arngrim
MD, medical doctor
Danish Headache Center