NCT00108264已完成1 期
Tumor RNA Transfected Dendritic Cell Vaccines
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 试验地点
- 2
研究概览
简要总结
The purpose of this study is to use dendritic cells transfected with amplified RNA from autologous tumor cells to develop a vaccine strategy for the treatment of prostate cancer in patients with disseminated disease.
详细描述
The specific aims are: 1) to evaluate, in a phase I clinical trial, the safety of vaccinating patients with dendritic cells transfected with RNA from autologous cancer cells; 2) to analyze the T cell responses induced by the treatment; and 3) to improve the efficacy of the treatment by developing methods to increase the induction of CD4+T cell responses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 10 Years 至 —（Child, Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Patients with a histologically confirmed diagnosis of metastatic prostate cancer stages D1 - D3 are eligible for this study.
- •They must not have a history of autoimmune disease, serious intercurrent chronic or acute illness, pulmonary disease, active hepatitis, serologic evidence for HIV, or be receiving corticosteroid or immunosuppressive therapy.
排除标准
- •Patients will be excluded from the study if they have received chemotherapy or other forms of immunotherapy in the 6 weeks prior to study entry.
研究者
研究点 (2)
Loading locations...
相似试验
终止
1 期
Messenger Ribonucleic Acid (mRNA) Transfected Dendritic Cell Vaccination in High Risk Uveal Melanoma PatientsUveal MelanomaNCT00929019Radboud University Medical Center23
Unknown
1 期
DC Vaccine Therapy Combined With Cytokine-Induced Killer Cell in Treating Patients With Renal Cell CarcinomaRenal Cell CarcinomaNCT00862303Fuzhou General Hospital100
已完成
2 期
Vaccination With Autologous Dendritic Cells Loaded With Autologous Tumor Lysate or Homogenate Combined With Immunomodulating Radiotherapy and/or Preleukapheresis IFN-alfa in Patients With Metastatic Melanoma: a Randomized "Proof-of-principle" Phase II StudyMalignant Melanoma of Skin Stage IIIMalignant Melanoma of Skin Stage IVNCT01973322Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS34
已完成
1 期
Personalized Cellular Vaccine for Glioblastoma (PERCELLVAC)GlioblastomaNCT02709616Guangdong 999 Brain Hospital10
已完成
2 期
Dendritic Cell Vaccination in Patients With Advanced Colorectal CancerColorectal NeoplasmsNCT00311272University Hospital, Gentofte, Copenhagen40