The Organ Protection of Astragalus in Subjects With Metabolic Syndrome

Phase 3

Completed

• Conditions: Metabolic Syndrome
• Interventions: Drug: high dose astagalus; Drug: low dose Astragalus

• Registration Number: NCT01847807
• Lead Sponsor: LanZhou University

Brief Summary

Metabolic syndrome have the damages on tissues and organs in heart、kindey and vessels. In this study, prospective randomized, controlled, parallel designed ,different doses of Astragalus Mongolia, Gansu Longxi produce treat on the MS patients, and then use real-time quantitative PCR and Western Blotting to detect the index of oxidative stress 、angiotensin-converting enzyme 2 mRNA expression and proteins.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2013-05-02
• Study First Submitted QC: 2013-05-06
• Study First Posted: 2013-05-07
• Primary Completion: 2015-06
• Status Verified: 2015-10
• Last Update Submitted: 2015-10-07
• Last Update Posted: 2015-10-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

1. age 18 years or older, meet the diagnostic criteria of MS
2. non-allergic with the astragalus
3. agree to conduct clinical trials and those who signed the informed consent

Exclusion Criteria

1. patients with resistant hypertension
2. renal disease requiring dialysis
3. heart failure NYHA ⅢorⅣ;
4. complications of diabetes
5. arteritis
6. cancer
7. thyroid disease
8. unstable coronary heart disease
9. peripheral vascular disease
10. acute cerebral vascular disease11.pregnancy、 planned pregnancy
11. patients with anti-oxidants
12. acute infection
13. other organic dysfunction, such as the liver, respiratory system, blood system, and other rheumatic diseases.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-dose Astragalus group	high dose astagalus	treatment with 10 gram astragalus
Low-dose Astragalus group	low dose Astragalus	treatment with 5 gram astragalus

Primary Outcome Measures

Name	Time	Method
index of cardiac function	one year	ues echocardiography to measure the cardiac function

Secondary Outcome Measures

Name	Time	Method
blood pressure	one year

Trial Locations

Locations (1)

Lanzhou University Second Hospital; 🇨🇳 Lanzhou, Gansu, China