Immunotyping lymph nodes in immune-mediated inflammatory diseases (IMIDs): lymph node cellular and molecular biomarkers in IMIDs

Recruiting

• Conditions: chronic inflammatory diseases; IMID; 10003816; 10023213

• Registration Number: NL-OMON55414
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 600

Inclusion Criteria

IMID patients
patients at risk of developing IMID
first degree relatives of IMID patients
healthy controls

Exclusion Criteria

patients unable to give informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in lymph node cellular composition and functional aspects in<br /><br>patients with established IMIDs, pre-clinical patients eventually developing<br /><br>IMIDs compared to pre-clinical patients that do not develop IMIDs, and of lymph<br /><br>nodes of first degree relatives compared to patients with IMIDs, all compared<br /><br>to lymph node tissue of healthy controls. Additionally, differences in cellular<br /><br>composition and functional aspects between lymph nodes and synovium/MRI in<br /><br>patients with established IMIDs or pre-clinical patients at risk of developing<br /><br>IMIDs (optional). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>