Immune Function of Colorectal Cancer Lymph Nodes

Not yet recruiting

• Conditions: Lymph Node; Colorectal Cancer

• Registration Number: NCT06319404
• Lead Sponsor: Shanxi Province Cancer Hospital

Brief Summary

Lymph nodes are very important immune organs in the human body and play an important role in the physiological and pathological activities of the body, especially in anti-tumor immunity. The role of regional draining lymph nodes in the development of colorectal cancer is still unknown. In this study, the role of lymph nodes in the development of colorectal cancer was investigated through multicenter and multi-omics data.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-01
• Study First Submitted: 2024-01-19
• Study First Submitted QC: 2024-03-12
• Last Update Submitted: 2024-03-12
• Study First Posted: 2024-03-20
• Last Update Posted: 2024-03-20
• Study Start: 2024-04-01
• Primary Completion: 2026-04-01
• Study Completion: 2026-04-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Stage I-III colorectal cancer patients undergoing radical surgery
• Complete imaging, pathology and genetics multi-omics data available
• 18-75 years old

Exclusion Criteria

• Patients with preoperative neoadjuvant therapy
• Patients with incomplete clinical information
• Patients with other malignant tumors
• Patients with acute infections or untreated chronic infections

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate the relationship between the type and number of immune cells in tumor draining lymph nodes and the activation of immune pathways is based on pathomics	2024.04-2026.04	Multiple immunohistochemistry was used to identify the type and number of immune cells and to explore the relationship between the activation state of immune pathways
The immune function of tumor draining lymph nodes of colorectal cancer patients was previously identified based on radiomics	2024.04-2026.04	Preoperative imaging data (CT, MRI) of patients were collected, and information in the images was extracted based on artificial intelligence algorithms. Predictive models were constructed to identify patients with good or bad immune function before surgery and guide subsequent treatment
To investigate the difference of immune pathway activation in tumor-draining lymph node based on genomics	2024.04-2026.04	BULK-RNA sequencing was performed on tumor draining lymph nodes to detect the activation of immune pathways in lymph nodes and explore the differences between them