DRKS00022777
Not yet recruiting
Not Applicable
Electrophysiological and functional imaging findings of central nervous representation of copingstrategies and their impact on cognitive performance in patients chronic relapsing pain and normal subjects.
Medizinische Fakultät Mannheim der Universität Heidelberg0 sites60 target enrollmentAugust 3, 2020
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- G43.9
- Sponsor
- Medizinische Fakultät Mannheim der Universität Heidelberg
- Enrollment
- 60
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Age: 18\-40 years
- •\- Patients must meet the diagnostic criteria of migraine with or without ICHD\-3 aura
- •\- Other types of headache may exist in addition to migraine if they can be classified differently by the patient
- •\- Migraine episode frequency 1\-14/month.
- •\- Migraine history for at least one year. First migraine episode at age \<50 years
- •\- Headache diary kept for 3 months before and 1 month after the examinations
- •\- Voluntary, informed consent to participate in the study
- •Healthy Subjects:
- •\- Age: 18\-40 years
- •\- Voluntary, informed consent to participate in the study
Exclusion Criteria
- •\- Patients must not have any contraindications to MRI examinations.
- •\- Patients must not have claustrophobia in need of treatment
- •\- Patients must not be pregnant. This is ensured by a ß\-HCG\- test in the urine.
- •\- Patients should be free of pain for at least 48 hours before the test. No pain medication should be taken.
- •\- Patients should not take centrally effective migraine prophylaxis or coanalgesics (especially anticonvulsants) or centrally attenuating substances (especially opioids).
- •\- If a migraine episode occurs in the 24 hours after the measurements, the measurement is stratified as preical.
- •\- Patients must be free of neurological and psychiatric diseases that could affect the outcome of the study. Subclinical depressive or anxiety\-related symptoms manifested in BDI and STAI are not exclusion criteria. The exclusion criterion is a higher degree of anamnestic impairment of kidney or liver function.
- •Test persons:
- •\- No relevant history of episodic headache. Freedom from sporadic headaches for at least 4 weeks before measurement.
- •\- Test persons must not have any contraindications to MRI examinations.
Outcomes
Primary Outcomes
Not specified
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