NL-OMON45518
Recruiting
Not Applicable
An observational neuroimaging and neurophysiological study investigating the visual pathway in Huntington*s disease. - Visual pathway in HD.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- hereditary neurodegenerative movement disorder
- Sponsor
- eids Universitair Medisch Centrum
- Enrollment
- 60
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\* Between 18 and 65 years of age at time of visit
- •\* Ability to undergo MRI scanning
- •\* Written informed consent must be obtained from the participant;If the participant is a manifest HD gene carrier:
- •\* Gene positive tested with CAG repeat length of \* 36 in the HTT gene
- •\* UHDRS\-TMS \> 5;If the participant is a premanifest HD gene carrier:
- •\* Gene positive tested with CAG repeat length of \* 36 in the HTT gene
- •\* UHDRS\-TMS \* 5;If the participant is a control subject:
- •\* Gene negative tested for HD or without family history of HD
- •\* No other known cognitive, neurological or psychiatric disorders
Exclusion Criteria
- •\* Impaired primary visual ability (\<0\.5\) or ophthalmic disorders
- •(including amblyopia or color vision deficiency)
- •\* Additional major co\-morbidities not related to HD
- •(e.g. cardiovascular diseases, hypertension, diabetes mellitus, and/or other neurological disorders)
- •\* History of severe head injury
- •\* Contra\-indication for MRI (metallic implants/devices, claustrophobia)
- •\* Participation in intervention trials
- •\* Pregnancy
- •\* Inability to understand the information about the protocol
Outcomes
Primary Outcomes
Not specified
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