?Effect of periodontal treatment on the level of serum inflammatory biomarkers
Phase 2
- Conditions
- Serum biomarkers in periodontal therapy.Chronic periodontitis
- Registration Number
- IRCT138706031081N1
- Lead Sponsor
- Guilan Universoty of Medical Sciences, Pro-vice-chancellor for research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
Being systemically healthy, No history of previous periodontal therapy and antibiotic use during the past three months, Body mass index between 20-27, Existence of at least 20 standing teeth without untreated periapical lesions, At least 15% of sites with more than or equal to 5 mm of clinical attachment loss and pocket depth. Radiographic evidence of bone loss
Exclusion criteria: Drugs such as: anticoagulants, steroids, anti-inflammatory drugs, immunosuppressant drugs, statins. Systemic diseases or conditions such as: Arthritis, GI disorders, skin diseases, bronchitis, Diabetes Mellitus, pregnancy, breast feeding and smoking.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum CRP levels. Timepoint: Before and four months after the intervention. Method of measurement: hs-CRP, by Enzyme- linked immunosorbent assay(ELIZA).;Plasma fibrinogen levels. Timepoint: Before and four months after the intervention. Method of measurement: Digital coagulation technique.;White blood cell counts. Timepoint: Before and four months after the intervention. Method of measurement: Counts in the peripheral blood samples.
- Secondary Outcome Measures
Name Time Method Probing pocket depth. Timepoint: Before and four months after intervention. Method of measurement: Williams periodontal probe calibrated in millimeters with probe tip of 0.4 mm in width.;Clinical Attachment Level. Timepoint: Before and four months after the intervention. Method of measurement: Williams periodontal probe calibrated in millimiters with a probe tip of 0.4mm width.;Plaque index scores. Timepoint: Before and four months after intervention. Method of measurement: Plaque index OLeary.;Gingival index. Timepoint: Before and four months after intervention. Method of measurement: Lenox & Kopezyk bleeding points index.