Relationship Between Spinopelvic Parameters and Clinical Symptoms of Low-grade Lumbar Isthmic Spondylolisthesis

Not Applicable

Completed

• Conditions: Isthmic Spondylolisthesis
• Interventions: Radiation: PI-LL

• Registration Number: NCT04968626
• Lead Sponsor: Peking University Third Hospital

Brief Summary

This was a retrospective study.PI and LL greatly influence IS and its progression. However, relationships between the spinopelvic parameters and clinical symptoms of patients with IS were not fully investigated in previous studies. Investigators hypothesized that spinopelvic parameters might be related to the clinical symptoms of IS patients. Therefore, the purpose of the present study was to investigate whether differences in spinopelvic parameters, especially spinopelvic alignment, may be associated with the clinical symptoms of low-grade IS patients.

Detailed Description

Isthmic spondylolisthesis (IS) is one of the most common types of spondylolisthesis, and spinopelvic parameters are closely related to the clinical symptoms of spinal diseases. In this study, investigators attempted to investigate the relationship between spinopelvic parameters and clinical symptoms of patients with low-grade (Meyerding grade I-II) isthmic spondylolisthesis (IS).

A total of 120 patients with low-grade IS and 106 asymptomatic adults were included in this study. Sex, age and body mass index (BMI) were also collected. Various spinopelvic parameters were evaluated in whole-spine standing-position X-rays. The following spinopelvic parameters were measured: pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT) and lumbar lordosis (LL). The clinical symptoms of the IS patients were assessed with the Japanese Orthopaedic Association (JOA) score and the visual analogue scale (VAS). Investigators compared spinopelvic parameters between the asymptomatic adults and the IS patients. Additionally, investigators investigated correlations between spinopelvic parameters and clinical symptoms.

Study Timeline

• Study Start: 2019-03-19
• Status Verified: 2020-03
• Primary Completion: 2021-01-01
• Study Completion: 2021-05-01
• Study First Submitted: 2021-06-27
• Study First Submitted QC: 2021-07-08
• Last Update Submitted: 2021-07-08
• Study First Posted: 2021-07-20
• Last Update Posted: 2021-07-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 226

Inclusion Criteria

• isthmic spondylolisthesis subjects had spondylolisthesis at L4 or L5 (Meyerding grade I-II) with whole-spine standing lateral images

Exclusion Criteria

• spondylolisthesis of other types (Degenerative, dysplastic, etc.);
• Lumbar infection and/or tumor diseases;
• A previous history of lumbar fusion surgery.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
IS GROUP	PI-LL	Patients who received an operation to treat their isthmic spondylolisthesis (IS, Meyerding grade I-II)

Primary Outcome Measures

Name	Time	Method
PI	through study completion, an average of 1 year	pelvic incidence
SS	through study completion, an average of 1 year	sacral slope
PT	through study completion, an average of 1 year	pelvic tilt
LL	through study completion, an average of 1 year	lumbar lordosis
PI-LL	through study completion, an average of 1 year	pelvic incidence minus lumbar lordosis

Secondary Outcome Measures

Name	Time	Method
VAS	through study completion, an average of 1 year	visual analogue scale
JOA	through study completion, an average of 1 year	The Japanese Orthopaedic Association (JOA)

Trial Locations

Locations (1)

Peking University Third Hospital; 🇨🇳 Beijing, Beijing, China