Effect of Transcutaneous Electrical Acupoint Stimulation on Postoperative Delirium and EEG Characteristic Parameters in Elderly Patients Undergoing Abdominal Surgery Under General Anesthesia
Overview
- Phase
- Not Applicable
- Intervention
- transcutaneous electrical acupoint stimulation
- Conditions
- Anesthesia
- Sponsor
- Zhihong LU
- Enrollment
- 226
- Locations
- 1
- Primary Endpoint
- Incidence of delirium by 7 days after surgery
- Status
- Completed
- Last Updated
- last month
Overview
Brief Summary
Transcutaneous electrical acupoint stimulation (TEAS) was reported to benefit the patients undergoing surgeries by reducing anesthetics consumption and decreasing anesthesia related adverse effects. Electroencephalogram (EEG) and EEG-related indicators are important indicators reflecting the conscious state of the brain, and different anesthetic drugs and anesthesia depths cause different EEG characteristic changes. The mechanism by which TEAS improves postoperative delirium (POD) is not clear, and whether changes in EEG characteristic parameters is involved needs to be further explored. Therefore, this study aims to observe the effect of TEAS at Neiguan and Shenmen acupoint on POD in elderly patients undergoing abdominal surgery, and to explore the EEG related mechanism underlying TEAS improving POD.
Investigators
Zhihong LU
Associate professor
Air Force Military Medical University, China
Eligibility Criteria
Inclusion Criteria
- •aged 65 years or older
- •American Society of Anesthesiologists (ASA) classification≤ Grade III
- •Patients scheduled for elective abdominal surgery under general anesthesia
- •Informed consent
Exclusion Criteria
- •Patients with severe central nervous system injury or severe cerebrovascular disease
- •Patients with cognitive dysfunction assessed by Confusion Assessment Method before surgery
- •Patients unable to cooperate with studies, such as psychiatric disorders or difficulty in communication
- •Patients with severe hepatic and renal insufficiency
- •Patients with severe respiratory diseases
- •Patients with contraindication for transcutaneous electrical stimulation, such as implanted electrophysiological devices, skin infection and damage at acupuncture points
- •Anticipated duration of anesthesia shorter than 2 hours or postoperative hospital stay shorter than 3 days
Arms & Interventions
Transcutaneous electrical stimulation
At the beginning of anesthesia induction, the electrodes are attached to the skin at the Neiguan point and Shenmen point and connected to the percutaneous acupoint electrical stimulation device (Hwato , Suzhou Medical Equipment Factory). Electrical stimulation is given.
Intervention: transcutaneous electrical acupoint stimulation
Control
At the beginning of anesthesia induction, the electrodes are attached to the skin at the Neiguan point and the Shenmen point without stimulation
Intervention: Control
Outcomes
Primary Outcomes
Incidence of delirium by 7 days after surgery
Time Frame: from end of surgery to 7 days after surgery
Delirium will be assessed by 3-minute Diagnostic Interview for Confusion Assessment Method
Secondary Outcomes
- Incidence of delirium by 1 day after surgery(From end of surgery to 1 day after surgery)
- Maximal decrease of regional cerebral oxygen saturation(From anesthesia induction to the end of surgery)
- Incidence of delirium by 3 days after surgery(From end of surgery to 3 days after surgery)
- electroencephalogram (EEG) alpha band power(From anesthesia induction to the end of surgery)
- opioid consumption for patient controlled analgesia(From end of surgery to 1 day after surgery)
- Incidence of major complications(From end of surgery to discharge from hospital, at an average of 7 days)
- The numerical rating scale of sleep quality(From end of surgery to 1 day after surgery)
- The numerical rating scale of pain(From end of surgery to 1 day after surgery)
- The numerical rating scale of sleep quality(From end of surgery to 3 days after surgery)
- The numerical rating scale of pain(From end of surgery to 3 days after surgery)
- The Quality of Recovery-15 Score by 3 days after surgery(From end of surgery to 3 days after surgery)
- number of attempts for patient controlled analgesia(From end of surgery to 1 day after surgery)
- total sleep time(From end of surgery to 1 day after surgery)