Salivary secretion in Parkinson's Disease patients with and without deep brain stimulatio

Conditions: G20
R68.2
Parkinson disease
Dry mouth, unspecified

Registration Number: DRKS00013232

Lead Sponsor: niklinik KölnAbteilung für Zahnerhaltung und Parodontologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 40

Inclusion Criteria

• Patients with Parkinson's disease: after DBS (Deep Brain Stimulation) at least 3 months ago (Arm 1) or without DBS (Arm 2)
• written informed consent
• minimum 18 years old

Exclusion Criteria

• actual or planned pregnancy during the study
• actual or anamnestic radiation or chemotherapy in the head/neck region
• actual or anamnestic parotid tumor
• actual or anamnestic surgery in the head/neck region
• Sjögren-Syndrome
• daily intake of symptom-relieving products against xerostomia, besides frequent water intake

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of Deep Brain Stimulation on salivation rates<br><br>Therefore among Parkinson's disease patients with and without deep brain Stimulation in the Medication- OFF Status, there is Salivation amount measurement. Salivation rates is done by collecting all produced saliva for five minutes, afterwards saliva amount is measured. Finally the Stimulator is turned on again.

Secondary Outcome Measures

Name	Time	Method
Effect of Dopamine on salivation rates, therefore, in the medication-OFF Status of Parkinson's disease patients without Deep Brain Stimulation, patients receive a standardized L-Dopa amount (200 mg), before and directly after salivation amounts are measured according to the primary endpoint. Masticatory function: participants chew 20 chewing cycles on two differently coloured chewing gums. Afterwards the degree of intermixing is documented by a specialized Software.