The effect of insulin-induced hypoglycemia on brain lactate accumulation and regional cerebral blood flow, an explorative study - The effect of hypoglycemia on brain lactate accumulation and CBF

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 21 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Inclusion criteria for healthy subjects;
•- Age: 18-50 years
•- Body-Mass Index: 18-30 kg/m2
•- Blood pressure: <160/90 mmHg;Inclusion criteria T1DM patients with normal hypoglycemic awareness
•- Diabetes duration >= 1 year
•- Age: 18-50 years
•- Body-Mass Index: 18-30 kg/m2
•- HbA1c: 42-75 mmol/mol (6-9%)
•- Outcome Clarke questionnaire: 0-1
•- Blood pressure: <160/90 mmHg;Inclusion criteria T1DM patients with hypoglycemia unawareness
•- Diabetes duration >= 1 year
•- Age: 18-50 years
•- Body-Mass Index: 18-30 kg/m2
•- HbA1c: 42-75 mmol/mol (6-9%)
•- Outcome Clarke questionnaire:>3
•- Blood pressure: <160/90 mmHg

•Exclusion criteria for healthy subjects;- Inability to provide informed consent;- Presence of any medical condition that might interfere with the study protocol, such as brain injuries, epilepsy, a major cardiovascular disease event or anxiety disorders;- Use of any medication, except for oral contraceptives;- MR(I) contraindications (pregnancy, severe claustrophobia, metal parts in body);Exclusion criteria for all T1DM patients;- Inability to provide informed consent;- Presence of any other medical condition that might interfere with the study protocol, such as brain injuries, epilepsy, a major cardiovascular disease event, anxiety disorders, or complications of T1DM (including neuropathy and retinopathy);- Use of any other medication than insulin, except for oral contraceptives or stable thyroxine supplementation therapy;- MR(I) contraindications (pregnancy, severe claustrophobia, metal parts in body)

发起方

niversitair Medisch Centrum Sint Radboud