Role of SWE-change After TIPS in the Prediction of Prognosis After TIPS

Completed

• Conditions: Portal Hypertension; Liver Cirrhoses
• Interventions: Diagnostic Test: Stiffness measurement

• Registration Number: NCT03072615
• Lead Sponsor: Jonel Trebicka

Brief Summary

The aim of our prospective multicenter study was to investigate the prognostic value of the acute and long-term changes of liver stiffness in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS).

Detailed Description

We included 83 patients receiving TIPS for prevention of rebleeding, therapy-refractory ascites or both. Hemodynamic parameters were assessed before TIPS and after TIPS insertion. 16 patients from Freiburg underwent TE immediately before and after TIPS. In 67 patients from Bonn, SWE of liver and spleen, as well as clinical and biochemical parameters were assessed before TIPS, seven days and six weeks after TIPS.

Study Timeline

• Study Start: 2013-04-01
• Primary Completion: 2015-11-30
• Study Completion: 2016-02-29
• Status Verified: 2017-03
• Study First Submitted: 2017-03-02
• Study First Submitted QC: 2017-03-02
• Last Update Submitted: 2017-03-02
• Study First Posted: 2017-03-07
• Last Update Posted: 2017-03-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 83

Inclusion Criteria

• TIPS insertion and had reliable SWE or TE measurement

Exclusion Criteria

• contraindication for TIPS
• no reliable SWE or TE measurement

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
2	Stiffness measurement	receiving SWE before and 7 days, 6 weeks and 3 months after TIPS
1	Stiffness measurement	receiving TE before and 30 min after TIPS

Primary Outcome Measures

Name	Time	Method
Survival	3 months

Secondary Outcome Measures

Name	Time	Method
Acute-on-chronic Lvier failure	3 months