Role of Digoxin in reducing induction-abortion interval in mid trimester termination of pregnancies
Not Applicable
- Conditions
- Health Condition 1: O048- (Induced) termination of pregnancywith other and unspecified complications
- Registration Number
- CTRI/2024/07/069918
- Lead Sponsor
- A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Woman with singleton pregnancy, equal to or more than 20 weeks of gestation opting for termination of pregnancy
Documented fetal cardiac activity
Exclusion Criteria
Chronic maternal illness (previous or active heart disease, chronic kidney or liver disease)
Preterm premature rupture of membranes
Abnormal serum potassium levels (below 3.5mmol/l or above 5.5 mmol/l)
Abnormal ECG
Known maternal digoxin hypersensitivity
More than 24 weeks of gestation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effectiveness of digoxin in inducing fetal death as determined by absence of fetal heartbeat on ultrasound 24 hours after the procedure. <br/ ><br>Comparison of Induction-Abortion interval of mid-trimester abortions in women with or without intra-amniotic digoxin administration.Timepoint: 24 hours after administration of intra-amniotic digoxin
- Secondary Outcome Measures
Name Time Method Comparison of the following parameters in women undergoing mid-trimester MTP with or without intra-amniotic digoxin instillation <br/ ><br>Success rate of mid-trimester abortions is defined as complete expulsion of products of conception <br/ ><br>Number of doses of misoprostol required <br/ ><br>Maternal systemic side effects in both the groups <br/ ><br>Timepoint: Interval between first dose of misoprostol and last dose of misoprostol