Ultra-high Field Imaging of the Cortico-striato-subthalamic Functional and Structural Connectivity to Improve Deep Brain Stimulation Surgery in Parkinson's Disease Patients

Maastricht University Medical Center1 site in 1 country20 target enrollmentApril 2014

ConditionsParkinson Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Parkinson Disease
Sponsor: Maastricht University Medical Center
Enrollment: 20
Locations: 1
Primary Endpoint: Voxels of the subthalamic nucleus that are structurally or functionally connected to the motor cortex.
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to investigate the segregation of the subthalamic nucleus into its motor and non-motor regions in patients with Parkinson's disease and healthy controls with the aid of ultra-high field magnetic resonance imaging.

Registry

clinicaltrials.gov

Start Date

April 2014

End Date

October 2016

Last Updated

10 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Maastricht University Medical Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Both groups:
•Mental competence
•Parkinson's disease patients scheduled for deep brain stimulation surgery
•Age and gender matched volunteers

Exclusion Criteria

•Both groups:
•Head injury
•Other neurological diseases other than Parkinson's disease
•Metallic prostheses or pacemaker in the subject's body or other contra indications for MRI
•Inability to abstain from dopaminergic drug use
•Parkinson's disease
•Use of medication affecting the central nervous system

Outcomes

Primary Outcomes

Voxels of the subthalamic nucleus that are structurally or functionally connected to the motor cortex.

Time Frame: One measurement, consisting of 1 MRI scan of 1 hour

Two brain areas are said to be structurally connected if they are connected by fiber tracks computed from diffusion weighted MRI data. Two brain areas are said to be functionally connected if they show statistically significantly correlated resting state functional MRI signals.

Secondary Outcomes

Brain areas structurally and functionally connected to the stimulation zone of the optimal electrode of operated Parkinson's patients.(One measurement, consisting of 1 MRI scan of 1 hour)
Brain areas that show an activation pattern measured with functional magnetic resonance imaging, that is correlated to a motor task.(One measurement, consisting of 1 MRI scan of 1 hour)
Strength of the structural and functional connectivity between the subthalamic nucleus and the motor cortex.(One measurement, consisting of 1 MRI scan of 1 hour)