Mapping and Stimulating the Limbic Areas of the Subthalamic Nucleus

Not Applicable

• Conditions: Mapping the Limbic STN Using Neuronal Responses
• Interventions: Device: Deep Brain Stimulation

• Registration Number: NCT01962194
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

The investigators hypothesize that the emotional and cognitive areas of the Subthalamic Nucleus (STN) have distinct electrophysiological properties and that specific stimulation of these areas can influence the mental and the emotional state. Parkinson's disease (PD; n=5) and obsessive-compulsive disorder (OCD; n=5) patients that are candidates for treatment with Subthalamic Nucleus (STN) Deep Brain Stimulation (DBS) will be recruited over a period of two years. The patients will be enrolled in a prospective, open label, clinical trial and will be followed for one year. No randomization or blinding will be used in this study.

Detailed Description

Not available

Study Timeline

• Status Verified: 2013-06
• Study First Submitted: 2013-09-25
• Study First Submitted QC: 2013-10-10
• Last Update Submitted: 2013-10-10
• Study First Posted: 2013-10-14
• Last Update Posted: 2013-10-14
• Study Start: 2013-12
• Primary Completion: 2015-12
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
PD and OCD paients for DBS intervention	Deep Brain Stimulation	Parkinson's disease (PD; n=5) and obsessive-compulsive disorder (OCD; n=5) patients that are candidates for treatment with STN DBS will be recruited over a period of two years.

Primary Outcome Measures

Name	Time	Method
Mapping the limbic-associative STN in human using neuronal (single units & Local Field Potential (LFP)) responses to emotional stimuli during surgery and long term LFP recordings in PD and OCD patients	two years	Mapping the limbic-associative STN in human using neuronal (single units \& Local Field Potential (LFP)) responses to emotional stimuli during surgery and long term LFP recordings in Parkinson's diseae (PD) and Obsessive Compulsive Disorder (OCD) patients

Trial Locations

Locations (1)

Hadassah Medical Center; 🇮🇱 Jerusalem, Israel