Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages

Not Applicable

Completed

• Conditions: Platelet Aggregation
• Interventions: Drug: Parecoxib/Valdecoxib; Drug: dipyrone; Drug: Ibuprofen; Drug: Acetaminophen; Other: Blood samples

• Registration Number: NCT00763997
• Lead Sponsor: Ruhr University of Bochum

Brief Summary

Dipyrone is suggested to inhibit the platelet aggregation comparable to th effect of traditional analgetic substances like Ibuprofen. To verify this hypothesis the investigators conducted the study in comparing patients undergoing traumatologic, visceral or plastic surgical procedures. The investigators randomized them to four groups receiving common analgetic doses of either dipyrone, acetaminophen (paracetamol) or valdecoxib/parecoxib. The investigators took blood samples before initiation of the study drug, 1h, 4hs and 24hs after first intake. The investigators compared the aggregation via aggregometry of platelet rich plasma.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-02
• Primary Completion: 2004-12
• Study Completion: 2004-12
• Status Verified: 2008-09
• Study First Submitted: 2008-09-29
• Study First Submitted QC: 2008-09-29
• Last Update Submitted: 2008-09-29
• Study First Posted: 2008-10-01
• Last Update Posted: 2008-10-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Planned traumatologic, orthopedic, visceral or plastic surgical procedures

Exclusion Criteria

• Prior intake of drugs with effect on the platelet aggregation
• Patients with diseases of the gastrointestinal systems
• Patients with cardiac or circulatory diseases
• Patients receiving corticoids
• Patients with cold or asthma
• ASA-classification > 3

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Blood samples	Dipyrone
2	Blood samples	Ibuprofen
3	Blood samples	Acetaminophen
4	Parecoxib/Valdecoxib	Parecoxib/Valdecoxib
4	Blood samples	Parecoxib/Valdecoxib
1	dipyrone	Dipyrone
2	Ibuprofen	Ibuprofen
3	Acetaminophen	Acetaminophen

Primary Outcome Measures

Name	Time	Method
Percentage of aggregation in platelet rich plasma fter 24 hours of treatment with analgetic doses	24 hours

Secondary Outcome Measures

Name	Time	Method
Percentage of aggregation of platelet rich plasma 1hour and 4 hours after initiation of study drug	4 hours

Trial Locations

Locations (1)

BG University Hospital Bergmannsheil GmbH; 🇩🇪 Bochum, Germany