Platelet Inhibition by Aspirin, Acetaminophen and NSAID
Not Applicable
Completed
- Conditions
- Hemostasis
- Interventions
- Drug: Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo
- Registration Number
- NCT00536068
- Lead Sponsor
- Kantonsspital Graubünden
- Brief Summary
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.
- Detailed Description
An in vivo study on healthy volunteers with combinations of well established drugs
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
Inclusion Criteria
- Healthy volunteers
Exclusion Criteria
- Administration of drugs affecting platelets
- History of bleeding
- Gastrointestinal disorders
- Hypersensitivity to aspirin and/or NSAID
- Pregnancy and breast feeding
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1, 2, 3, 4 Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo 1. acetylsalicylic acid 100 mg/po,acetaminophen 3x1g/po 2. acetylsalicylic acid 100 mg/po,diclofenac 3x50mg/po 3. acetylsalicylic acid 100 mg/po,naproxen 3x250mg/po 4. acetylsalicylic acid 100 mg/po,placebo 3x1/po
- Primary Outcome Measures
Name Time Method platelet aggregation 5 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kantonsspital Graubünden, Department of Internal Medicine
🇨🇭Chur, Switzerland