The effect of memantine on the pain relief after orthopedic surgery

Phase 2

• Conditions: Acute pain.; Acute pain

• Registration Number: IRCT2017062413364N4
• Lead Sponsor: Vice Chancellor for Research and Technology of Shahid Beheshti University Of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

patients undergoing elective orthopedic surgery of the lower limbs (calf fracture); aged 18-65 years;physical health status of ASA 1 or 2
Exclusion criteria:ASA physical health status of 3 or 4; diseases of the respiratory system, heart, brain and endocrine glands;any opioid consumption in one week prior to surgery;sensitivity to opioid used in the study;a history of mental illness;MAOIs or SSRIs consumption during 4 weeks before the surgery; pregnancy;history of stroke;type 1 and 2 diabetes mellitus.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: 6, 12, 24, 36 and 48 hours after the surgery. Method of measurement: visual analog score.

Secondary Outcome Measures

Name	Time	Method
Sedation scores. Timepoint: 6, 12, 24, 36 and 48 hours after the surgery. Method of measurement: 0 for restless, 1 for quiet, 2 for sleepy, 3 for confused but with respond to verbal commands, 4 for no response to verbal commands, and 5 for no response to painful stimulus.;Nausea and vomiting. Timepoint: 6, 12, 24, 36 and 48 hours after the surgery. Method of measurement: 1 for mild nausea without the need for medication, 2 for nausea needing medication, 3 for nausea and lack of response to anti-nausea drugs.;Patient satisfaction. Timepoint: At the end of 48 hours post operation. Method of measurement: 0 for absolutely no pain, 1 for sometimes moderate pain, 2 for always moderate pain, 3 for sometimes severe pain, 4 for always moderate pain and sometimes severe pain, and 5 for always severe pain.