Study Aiming at Researching Diagnostic Markers for the Recognition of Precancerous States, Tracking, Follow-up, and the Identification of New Therapeutic Targets for Mesothelioma in Patients With Atypical Mesothelial Hyperplasia.

OBJECTIVES:

Primary

• Determine if mesothelin and osteopontin in serum can serve as early markers of malignant transformation into mesothelioma.

Secondary

• Determine if there are cytological, histological, immunohistochemical, and molecular markers of precancerous disease in tissue samples.
• Determine if SV40 has a carcinogenic role.
• Determine the relationship between the serum concentration of mesothelin and/or osteopontin and the expression of other markers and with clinical progression.