DRKS00007660已完成不适用
Fetotoxical risk analysis of maternal triptan therapy during pregnancy in the context of migraine disorder
Pharmakovigilanzzentrum Embryonaltoxikologie Charité-Universitätsmedizin0 个研究点目标入组 2,640 人开始时间: 2015年9月16日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,640
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- one 至 one（—）
- 性别
- Female
入选标准
- •all cohorts: prospective assessment of gestation (outcome and results of prenatal diagnostics are still unknown and the data can be assessed prospectively)
- •study group:
- •exposure to triptans for migraine, exposure interval at least one day between first day of the last menstrual period and delivery (therapy may have started earlier and can have lasted longer)
- •disease comparison group:
- •maternal migraine not exposed to triptans between last menstrual period and delivery
- •control group:
- •pregnancies without maternal migraine and without any triptans medication during pregnancy (over a period from last menstrual period to delivery);
- •matched with study group by year of ascertainment
排除标准
- •all cohorts: retrospectively ascertained pregnancies
- •control group:
- •migraine disorder, acute malignancies, maternal exposure considered as teratogenic or fetotoxic:
- •acenocoumarol, lenalidomide, carbamazepine, methotrexate, mycophenolate, phenobarbital, phenytoin, retinoids (acitretin, adapalen, isotretinoin, tazaroten, tretinoin), thalidomide, topiramate, valproic acid, warfarin, angiotensin-converting enzyme (ACE)-inhibitors and angiotensin II receptor antagonists
研究者
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