NCT02852018已完成不适用
Identification of Genetic Markers Modulating Rhythmic Risk Among Patients With Severe Cardiomyopathy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,500
- 试验地点
- 18
- 主要终点
- Prevalence of polymorphisms pre-selected candidates (or by direct sequencing by High Resolution Melting).
研究概览
简要总结
The aim of this project is to identify common genetic polymorphisms associated with the occurrence of rhythmic events in patients with severe cardiomyopathy.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients implanted for primary prevention, an implantable cardioverter defibrillator (ICD) single or double room, for severe cardiomyopathy (EF <35%)
- •Patients with ischemic cardiomyopathy or idiopathic dilated cardiomyopathy.- "Appropriate treatment" group: patients who had a rhythmic event (before or after inclusion) appropriately treated either by administering an electric shock or by antiarrhythmic stimulation
- •Group "no event" patients who have never received treatment or electrical antiarrhythmic stimulation and with a minimum follow-up of three years before inclusion and did not receive proper treatment during the follow up period of the study
排除标准
- •Patients implanted with an ICD for primary prevention in the context of a family hereditary disease (long QT syndrome, Brugada syndrome, hypertrophic cardiomyopathy, ventricular tachycardia catecholergic right ventricular dysplasia ...).
- •Patients with left ventricular function greater than 35%.
- •Patients implanted with a defibrillator function resynchronization.
- •Patients minors, adults under guardianship and protected persons are eligible under this project.
结局指标
主要结局
Prevalence of polymorphisms pre-selected candidates (or by direct sequencing by High Resolution Melting).
时间窗: 4 years
Identification of polymorphisms frequent (> 5% in the general population) by association study ( "Genome Wide Association Study '(GWAS)) using genotyping technology broadband Axiom (Affymetrix).
时间窗: 4 years
次要结局
未报告次要终点
研究者
研究点 (18)
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