The clinical efficacy and brain plasticity mechanism research of acupuncture for patients with moderate depression: a randomized controlled trial

Phase 1

Recruiting

• Conditions: moderate depression

• Registration Number: ITMCTR2000003026
• Lead Sponsor: Guangdong Provincial Hospital of Tradition Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

(1) Aged range 18-50 years, male or female, right handed;
(2) Met the diagnosis criteria of depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5);
(3) Hamilton Depression Scale (HAMD-24) score is 27-35 (Moderate depression);
(4) No medical treatment, physical and psychological therapy more than 3 weeks or maintain stable medical treatment at least 3 weeks;
(5) People who volunteer to participate in this study and sign the written informed consent.

Exclusion Criteria

(1) History of self harm or suicide;
(2) History of schizophrenia, bipolar disorder or severe personality disorder;
(3) History of alcohol abuse or drug dependence;
(4) History of severe traumatic brain injury or epilepsy;
(5) Participants who have serious cardiovascular diseases, liver diseases or kidney diseases;
(6) People who refuse acupuncture treatment during the trial;
(7) Metal implant in skull or pacemaker;
(8) Women in pregnant or lactating.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
HAMD-24;

Secondary Outcome Measures

Name	Time	Method
BDI;Contralateral silent period (CSP);Motor evoked potentials (MEPs);Rating Scale for Side Effects (SERS);The resting motor threshold (rMT);