Effect of Helicobacter infection on zinc and iron absorptio

Completed

• Conditions: Helicobacter pylori infection; Infections and Infestations; Bacterial infection of unspecified site

• Registration Number: ISRCTN46133211
• Lead Sponsor: niversity of Chile, Institute of Nutrition and Food Technology (INTA) (Chile)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01-06
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

1. Asymptomatic adults
2. Aged 35 - 45 years (women) and aged 25 - 45 years (men)

Exclusion Criteria

Gastrointestinal symptoms

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessed on days 17 and 38 of the study:<br>1. Fractional iron absorption, assessed by Eakins and Brown's double-isotope technique<br>2. Fractional zinc absorption, determined from the ratio of urinary enrichment of oral doses (67Zn and 70Zn) as a proportion of urinary enrichment of intravenous dose (68Zn)

Secondary Outcome Measures

Name	Time	Method
1. Intragastric pH, assessed by the urine acid output test, assessed on days 1 and 24 of the study<br>2. Pepsinogen I and pepsinogen II will be determined by radioimmunoassay, assessed on day 3 of the study. Haemoglobin, serum iron, TIBC and transferrin saturation, serum ferritin and serum zinc, assessed on day 3 of the study <br>7. High sensitivity C-reactive protein, assessed on day 3 of the study