Does Moderate Physical Activity in Chronic Hemodialysis Patients Reduce Inflammation Via Inhibition of Proinflammatory Monocyte Activity?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Composition of monocyte subpopulations as defined by CD14 and CD16 expression
研究概览
简要总结
The purpose of this study is to observe a potential benefit of moderate physical activity by using bed mounted cycles during hemodialysis treatment sessions on inflammatory markers in the blood of patients with end-stage renal disease (ESRD).
详细描述
Patients with ESRD on chronic hemodialysis patients frequently have elevated markers of inflammation (e.g., serum CRP values) and accumulation of proinflammatory monocyte populations in the circulation. The level of inflammation is highly predictive for cardiovascular disease and mortality. Physical activity has been shown to improve dialysis efficacy by improving the elimination of retention solutes. In healthy individuals, sports activity influences inflammatory immune parameters. The study will observe the influence of moderate physical activity (using a bed mounted cycle for 30min during dialysis thrice weekly) on circulating monocyte subpopulations and inflammatory proteins over a 9 month period in 16 chronic hemodialysis patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic hemodialysis treatment for at least three months
- •three dialysis sessions per week
- •good general clinical condition
- •stable hemodynamics during the most recent three dialysis sessions
排除标准
- •conditions making the patient unable to use the bed mounted cycle (amputations, joint disease etc)
- •clinically obvious acute infections
- •active malignancy
- •pathologic results of spiroergometry or echocardiography that imply an elevated risk of participation
- •myocardial infarction within the last 12 weeks
- •uncontrolled arterial hypertension
- •uncontrolled diabetes mellitis with frequent hypoglycemia
- •unability to understand and consent the protocol
结局指标
主要结局
Composition of monocyte subpopulations as defined by CD14 and CD16 expression
时间窗: 6 months
次要结局
- Serum CRP values(6 months)
- Dialysis quality (kt/V, URR)(6 months)
研究者
Matthias Girndt
Professor of Internal Medicine
Martin-Luther-Universität Halle-Wittenberg