Exercise as an Adjunct Therapy to Reduce Blood Pressure in Chronic Kidney Disease
Not Applicable
Completed
- Conditions
- Focus Chronic Kidney Disease With Hypertension
- Interventions
- Behavioral: Exercise
- Registration Number
- NCT02112825
- Lead Sponsor
- University of Minnesota
- Brief Summary
The general objective of the study is to investigate the effect of regular aerobic exercise on resting and 24-hr blood pressure levels in men and women with stage 3-4 kidney disease and hypertension.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
-
• Non-diabetic and >18 years of age
- Diagnosed kidney disease with associated hypertension:
- Non-nephrotic range proteinuria at diagnosis
- No active glomerular disease or concomitant systemic inflammatory disease (e.g. lupus)
- Systolic blood pressure >130 and/or diastolic blood pressure >80 mm Hg (on medication)
- An estimated glomerular filtration rate of between 60 ml/min and 15 ml/min.
- Individuals must be able to provide informed consent
- Perform walking exercise training on a treadmill
- Be able to participate in a 12-week supervised exercise program.
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Exclusion Criteria
- Currently participating in a formal exercise program
- Diabetes, active glomerular disease, or systemic inflammatory disease
- Requiring dialysis
- Have an Hematocrit <27%
- Uncontrolled hypertension (>200/110mmHg)
- Peripheral vascular disease.
- An inability to understand English or give consent. Other exclusion criteria are: any contraindications to exercise testing or training as indicated by the American College of Sports Medicine guidelines such as: Unstable coronary heart disease and symptomatic heart failure, exercise capacity limited by health problems such as angina, severe arthritis, or extreme dyspnea on exertion, progressive neuromuscular disease, pulmonary disease, or having undergone a coronary revascularization within the past 6 months prior to enrollment.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Exercise Exercise 12 weeks of blended supervised-home based exercise 3-4 times per week for 30-45 minutes
- Primary Outcome Measures
Name Time Method blood pressure at week 0 and at week 12 resting and 24-hour ambulatory blood pressure
- Secondary Outcome Measures
Name Time Method effective vascular compliance at week 0 and at week 12 Pulse wave velocity estimated systemic vascular resistance
endothelial function at week 0 and at week 12 measured by brachial artery flow mediated vasodilation
biomarkers associated with blood pressure at week 0 and at week 12 Circulating levels of angiotensin 2 Circulating levels of endothelin 1 asymmetric dimethylarginine
Trial Locations
- Locations (1)
University of Minnesota
🇺🇸Minneapolis, Minnesota, United States