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Exercise as an Adjunct Therapy to Reduce Blood Pressure in Chronic Kidney Disease

Not Applicable
Completed
Conditions
Focus Chronic Kidney Disease With Hypertension
Interventions
Behavioral: Exercise
Registration Number
NCT02112825
Lead Sponsor
University of Minnesota
Brief Summary

The general objective of the study is to investigate the effect of regular aerobic exercise on resting and 24-hr blood pressure levels in men and women with stage 3-4 kidney disease and hypertension.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
40
Inclusion Criteria
  • • Non-diabetic and >18 years of age

    • Diagnosed kidney disease with associated hypertension:
    • Non-nephrotic range proteinuria at diagnosis
    • No active glomerular disease or concomitant systemic inflammatory disease (e.g. lupus)
    • Systolic blood pressure >130 and/or diastolic blood pressure >80 mm Hg (on medication)
    • An estimated glomerular filtration rate of between 60 ml/min and 15 ml/min.
    • Individuals must be able to provide informed consent
    • Perform walking exercise training on a treadmill
    • Be able to participate in a 12-week supervised exercise program.
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Exclusion Criteria
  • Currently participating in a formal exercise program
  • Diabetes, active glomerular disease, or systemic inflammatory disease
  • Requiring dialysis
  • Have an Hematocrit <27%
  • Uncontrolled hypertension (>200/110mmHg)
  • Peripheral vascular disease.
  • An inability to understand English or give consent. Other exclusion criteria are: any contraindications to exercise testing or training as indicated by the American College of Sports Medicine guidelines such as: Unstable coronary heart disease and symptomatic heart failure, exercise capacity limited by health problems such as angina, severe arthritis, or extreme dyspnea on exertion, progressive neuromuscular disease, pulmonary disease, or having undergone a coronary revascularization within the past 6 months prior to enrollment.
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Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
ExerciseExercise12 weeks of blended supervised-home based exercise 3-4 times per week for 30-45 minutes
Primary Outcome Measures
NameTimeMethod
blood pressureat week 0 and at week 12

resting and 24-hour ambulatory blood pressure

Secondary Outcome Measures
NameTimeMethod
effective vascular complianceat week 0 and at week 12

Pulse wave velocity estimated systemic vascular resistance

endothelial functionat week 0 and at week 12

measured by brachial artery flow mediated vasodilation

biomarkers associated with blood pressureat week 0 and at week 12

Circulating levels of angiotensin 2 Circulating levels of endothelin 1 asymmetric dimethylarginine

Trial Locations

Locations (1)

University of Minnesota

🇺🇸

Minneapolis, Minnesota, United States

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