The Role of Exercise Training in the Treatment of Resistant Hypertension
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Resistant Hypertension
- Sponsor
- Aveiro University
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- Ambulatory blood pressure
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The main purpose of this study is to assess whether exercise training reduces ambulatory blood pressure in patients with resistant hypertension. To accomplish these goals 60 patients with resistant hypertension will be recruited and randomized into exercise training or control groups and followed up for 6 months. The patients in the exercise group will participate in a 3-month outpatient program. The control group will receive usual medical care. At baseline, after the intervention and 3 months after the end of the intervention both groups will undergo several evaluations, including casual and ambulatory blood pressure, body composition, cardiorespiratory fitness, quality of life, arterial stiffness, autonomic function, and endothelial and inflammatory biomarkers.
Investigators
Fernando Ribeiro
Adjunct Professor
Aveiro University
Eligibility Criteria
Inclusion Criteria
- •confirmed resistant hypertension, who in the previous 3 months had unchanged medication
Exclusion Criteria
- •Patients with secondary hypertension
- •Evidence of target organ damage
- •Patients with heart failure
- •Previous cardiovascular event
- •Peripheral artery disease
- •Renal failure
- •Chronic obstructive pulmonary disease
- •Systolic office blood pressure superior to 180 mmHg
- •Biomechanical limitations to physical activity
- •Those participating in regular physical activity
Outcomes
Primary Outcomes
Ambulatory blood pressure
Time Frame: Change from Baseline in Blood Pressure at 3 months
Blood pressure
Secondary Outcomes
- Arterial stiffness(Change from baseline to 3 months)
- Heart rate variability(Change from baseline to 3 months)
- Inflammation(Change from baseline to 3 months)
- Oxidative stress(Change from baseline to 3 months)
- Circulating number of endothelial progenitor cells, circulating endothelial cells, nitric oxide and endothelial Nitric Oxide Synthase(Change from baseline to 3 months)
- Daily physical activity(Change from baseline to 3 months)
- Casual blood pressure(Change from baseline to 3 months)
- Dietary intake(Change from baseline to 3 months)
- VO2 max(Change from baseline to 3 months)
- Body composition(Change from baseline to 3 months)
- Health-related quality of life(Change from baseline to 3 months)