Effect of Atorvastatin in Prophylaxis of Migraine Attacks in Patients with Classic Migraine Compared to Standard Treatment Sodium Valproate
- Conditions
- Migraine.Migraine
- Registration Number
- IRCT20180106038242N1
- Lead Sponsor
- Ahvaz University of Medical Sciences Research ?Assistance
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 68
Age 18 to 65 years
Having at least 3 migraine attacks per month
Patients who have fewer than three attacks per month, provided that they affect high-intensity attacks and the patient's life
Have a normal serum level of vitamin D3
Patients with classical migraine
Patients who do not sign a form of moral consent.
Patients with chronic headaches (more than 15 attacks per month)
Patients receiving Statin for other diseases
Severe renal failure (GFR <30 ml / min)
Creatine Kinase more than 3 times normal
Liver enzymes more than twice the normal range
The increase in liver enzymes during treatment is more than 3 times the normal
Other patients who use drugs other than sodium valproate to treat their migraines and have their disease controlled or sodium valproate, and the disease is under control
Pregnant women
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of migraine pain according to the Visual Analogue Scale (VAS). Timepoint: The measurement of pain intensity based on the Visual Analogue Scale (VAS) at the beginning of the study (before the intervention) and And one day after the intervention(4 weeks after the onset of Atorvastatin). Method of measurement: Visual Analogue Scale (VAS).;The Rate of Migraine Attacks. Timepoint: The question of the history of migraine attacks in a 8-week interval. Method of measurement: Ask The Patient.
- Secondary Outcome Measures
Name Time Method