Comparison of 2 resuscitation fluids (balanced salt and normal saline) in children With Septic Shock
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Children 2 month to � 15 years with features of septic shockHealth Condition 2: A419- Sepsis, unspecified organism
- Registration Number
- CTRI/2016/12/007594
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 708
Inclusion Criteria
Children 2 month to � 15 years with features of shock requiring at least two fluid boluses (20 ml/kg) would be included.
Exclusion Criteria
1.Children with cardiogenic shock
2.Known patient with chronic kidney disease with baseline deranged renal function (eGFR < 90 ml/1.73 m2/min)
3.Severe malnutrition
4.Children whose parents refuse to give an informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of children with acute kidney injuryTimepoint: 1st 7 days after initial fluid resuscitation
- Secondary Outcome Measures
Name Time Method Difference in pH, serum bicarbonate and strong ion differenceTimepoint: 1. At baseline and 6 hours <br/ ><br>2. At Baseline and 24 hours <br/ ><br>;MortalityTimepoint: During ICU stay;Proportion of patients with serum chloride levels 108 meq/LTimepoint: At 6 and 24 hours;Total fluids received as bolusesTimepoint: In first 6 and 24 hours