PCT and Clinical Algorithm for Determination of Duration of Antibiotics
- Conditions
- Infection
- Registration Number
- NCT01572831
- Lead Sponsor
- Fraser Health
- Brief Summary
Patients in the ICU whose infection is resolving will be randomized to standard duration of antibiotics compared to duration determined by a combination of a procalcitonin value and a simple evaluation of clinical status.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1
- Adult patients (19 years and older) treated with ABx for reasons other than prophylaxis within the last 24 hours and who are admitted to a critical care environment.
-
Declined consent
-
Any infection that according to evidence-based guidelines which would usually receive more than 2 weeks of antibiotic therapy including, but not limited to;
- Infective endocarditis
- Osteomyelitis
- Undrained abscess
-
Not expected to survive 48 hours
-
Immunosuppression (HIV positive, any immunosuppressive medications, any steroid dose, neutrophil count less than 1.0)
-
Previously enrolled in this study
-
Presently enrolled in a separate study which is felt by study investigators to have biological or clinical process in conflict with this study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Antibiotic- free days and alive at 14 days after ICU admission 14 days
- Secondary Outcome Measures
Name Time Method mortality at 28 days 28 days mortality at 90 days 90 days ventilator days at 28 days 28 days colonization/infection with VRE/MRSA over next 30 days 30 days relapsed infection 30 days rates of CDAD 30 days ICU free days at 28 days 28 days duration of abx in control arm for those with and without formal stewardship programs 14 days
Trial Locations
- Locations (1)
Royal Columbian Hospital
🇨🇦New Westminster, British Columbia, Canada
Royal Columbian Hospital🇨🇦New Westminster, British Columbia, Canada