A study comparing serum periostin levels in Caucasian and Chinese adult populations without asthma or any other significant respiratory co-morbidity, and comparing serum periostin levels in a Chinese adult population with mild asthma versus moderate/ severe asthma.

Medical Research Institute of New Zealand0 个研究点目标入组 188 人开始时间: 2014年1月31日最近更新: 2020年1月13日

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•Between 18 to 75 years of age
•Able to provide written informed consent
•Born in New Zealand, Australia, China, Hong Kong, Taiwan, Singapore or other countries in Asia
•Of Chinese descent, more specifically: Both parents that self-identify as ethnic Chinese
•Residing in New Zealand for more than one year at Visit 1
•For Group 1 (non-asthmatics), at least 10 male and 10 female participants will be recruited to each of the following four age bands; 18-30, 31-45, 46-60 and 61-75 years.
•For Group 2 (asthmatics), participants will have a current diagnosis of asthma.
•34 will have mild asthma (treated with a SABA) and 34 will have moderate/severe asthma (treated with an ICS).

•Doctor’s diagnosis of Asthma, Chronic Bronchitis or COPD
•Wheezing or use of respiratory inhalers in the past 12 months
•Systemic Corticosteroids within the last three months
•Group 1 and 2
•Current smoker, or former smoker with a smoking history of greater than 10 pack-years.
•Known pregnancy
•First six weeks post-partum
•Significant co morbidities (determined at investigator discretion)
•Hospital admission within last three months
•Surgery within last three months, determined at investigator discretion (this includes all major surgery requiring general anaesthetic, dental extractions and root canal procedures. This does not include minor procedures, including but not limited to mole or wart removal, dental fillings etc).
•Bone fracture within the last three months
•Active (current, or within the three weeks prior to the visit) upper or lower respiratory tract infection
•Any other safety concern at the investigator’s discretion

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