NCT02264951已完成不适用
Short Fatty Acids-induced Release of GLP-1 in Humans
Glostrup University Hospital, Copenhagen0 个研究点目标入组 12 人开始时间: 2013年10月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 主要终点
- plasma GLP-1
研究概览
简要总结
This study compared the incretin-releasing effect of C8-diet oil and tributyrin with that of 20 ml olive oil on a molar basis in human volunteers.
详细描述
A structured triglyceride (1,3-di-octanoyl-2-oleoyl-glycerol, called C8-diet oil), which upon digestion results in generation of two medium-chain fatty acids and 2-oleoyl-glycerol (2-OG), may lead to activation of GPR119 only, since medium fatty acids are poor agonists for fatty acid receptors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Caucasian healthy male subjects
- •Body mass index (BMI) 19 to 25 kg/m2
- •Informed consent
排除标准
- •Diabetes mellitus
- •Gastrointestinal diseases or operations interacting with intestinal absorption
结局指标
主要结局
plasma GLP-1
时间窗: 2 hours postprandial
plasma GIP
时间窗: 2 hours postprandial
次要结局
- plasma neurotensin(2 hour postprandial)
- plasma CCK(2 hour postprandial)
- plasma insulin(2 hours postprandial)
- plasma PYY(2 hours postprandial)
- plasma glucose(2 hours postprandial)
研究者
Katrine Bagge Hansen
MD, PhD
Glostrup University Hospital, Copenhagen
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