Neural and Cognitive Mechanisms of Depression and Anxiety: a Multimodal MRI Study

• Conditions: Depression

• Registration Number: NCT02888509
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

To explore the neural and cognitive mechanisms of depression (including unipolar depression and Bipolar disorder) and anxiety using multimodal MRI techniques.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-06
• Status Verified: 2016-08
• Study First Submitted: 2016-08-30
• Study First Submitted QC: 2016-08-30
• Last Update Submitted: 2016-08-30
• Study First Posted: 2016-09-05
• Last Update Posted: 2016-09-05
• Primary Completion: 2017-01
• Study Completion: 2017-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Age range from 16 to 55 years old.
• All patients were interviewed by two experienced psychiatrists using the Structured Clinical Interview for DSM-IV (patient edition)

Exclusion Criteria

• Schizophrenia, mental retardation or personality disorder, any history of loss of consciousness, substance abuse, serious medical or neurological illness.
• Subjects with contraindications to MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain structural and functional changes in patients	one time point	Structure and function changes in patients will be assessed by Voxel-based morphometry analysis for structural changes, as well as Regional homogeneity, Amplitude of lowfrequency fluctuation, etc, for functional changes.

Trial Locations

Locations (1)

School of Life Science and Technology, University of Electronic Science and Technology; 🇨🇳 Chengdu, Sichuan, China