TMAO and Atherosclerosis in HIV

Completed

• Conditions: Carotid Artery Plaque
• Interventions: Other: No intervention

• Registration Number: NCT03416257
• Lead Sponsor: Albert Einstein College of Medicine

Brief Summary

In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery plaque, assessed by repeated B-mode carotid artery ultrasound imaging over a 7-year period, in women and men with and without HIV infection from the WIHS (Women Interagency HIV Study) and MACS (Multicenter Aids Cohort Study).

Detailed Description

Not available

Study Timeline

• Study Start: 2004-04-12
• Primary Completion: 2013-09-01
• Study Completion: 2017-04-04
• Study First Submitted: 2018-01-24
• Study First Submitted QC: 2018-01-24
• Study First Posted: 2018-01-31
• Status Verified: 2018-06
• Last Update Submitted: 2018-06-12
• Last Update Posted: 2018-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 737

Inclusion Criteria

• participants who underwent carotid artery imaging for plaque assessment at a baseline visit (2004-2006) and at a follow-up visit (2011-2013).

Exclusion Criteria

• a history of coronary heart disease, individuals with prevalent diabetes or prevalent carotid artery plaques at baseline

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
MACS	No intervention	Multicenter AIDS Cohort Study
WIHS	No intervention	Women's Interagency HIV Study

Primary Outcome Measures

Name	Time	Method
incident carotid artery plaque	2011-2013	assessed by repeated B-mode carotid artery ultrasound imaging