跳至主要内容
临床试验/NCT03150342
NCT03150342Unknown不适用

Presentations of Hypertrophic Cardiomyopathy on Myocardial Perfusion Imaging

Far Eastern Memorial Hospital1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2017年5月8日最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
试验地点
1
主要终点
MPI results

研究概览

简要总结

Chest pain and myocardial ischemia are prevailing features in patients with hypertrophic cardiomyopathy (HCM). Recently introduced single-photon emission computed tomography (SPECT) cameras with solid-state cadmium-zinc-telluride (CZT) detectors have been shown to decrease imaging time and improved the imaging quality of gated myocardial perfusion imaging (MPI). The investigators also correlate the MPI parameters with echocardiographic parameters. This study is to examine the spatial distribution of stress perfusion abnormalities and tissue injury in patients with HCM using a CZT SPECT camera.

详细描述

The investigators will retrospectively evaluate myocardial perfusion patterns and cardiac function with Thallium (Tl)-201 gated dipyridamole MPI in patients with clinical diagnosis of HCM and patent coronary angiography between January 2013 and October 2016. The inclusion criteria included a spade-like configuration on left ventriculogram, or echocardiographic findings suggestive of HCM. The participants will be then divided into the following three groups: apical, concentric and septal forms. Regional perfusion would be analyzed using a 17-segment model from 0-4 degree (0=normal, to 4=absent perfusion); and summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS) were calculated. Gated SPECT would be processed by quantitative gated SPECT (QGS) software (Cedars-Sinai Medical Center, Los Angeles, CA, USA) and ejection fraction phase analysis. Diastolic parameters would be also acquired by Doppler echocardiography, and correlated with MPI parameters.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Retrospective

入排标准

年龄范围
20 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • clinical diagnosis of HCM and patent coronary angiography between January 2013 and October 2016.

排除标准

  • patient with prior myocardial ischemia, conduction abnormality, valvular disease or other cardiomyopathy

结局指标

主要结局

MPI results

时间窗: January 2013 and October 2016.

including perfusion abnormalities, and ejection fraction phase analysis results

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Szu-Ying Tsai

Resident Physician, department of nuclear medicine

Far Eastern Memorial Hospital

研究点 (1)

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