Fentanyl Sublingual Spray for the Treatment of Acute Procedure-related Pain in a Monitored Setting

Phase 3

Withdrawn

• Conditions: Chronic Pain
• Interventions: Drug: Fentanyl Sublingual Spray (FSS); Drug: Placebo Sublingual Spray (PSS)

• Registration Number: NCT02138409
• Lead Sponsor: INSYS Therapeutics Inc

Brief Summary

Participants will be selected from patients who have been scheduled at the site for treatment of chronic pain without sedation. They will receive either fentanyl sublingual spray or a matching placebo sublingual spray that delivers no medication.

Participants may take pain killers at any time after the procedure for pain relief. They will be given a diary card, which they will take home. They will record the name of the medication taken, the time, and dosage.

The study coordinator will call participants about 24 hours after the procedure to collect information from the diary card and follow up information about pain and side effects (adverse events) after they left the site.

Detailed Description

Participants will be separated into opioid-experienced and opioid-naïve groups. Participants in each group will be randomly allocated in a 3:1 ratio to receive fentanyl sublingual spray (FSS) or a matching placebo sublingual spray (PSS) 10 minutes before the scheduled procedure. Based on FDA guidelines, opioid-experienced FSS participants will receive FSS 400 µg, and opioid-naïve FSS participants will be further randomized in a 1:1 ratio to receive either 100 µg or 200 µg. All participants randomized to placebo receive the same matching PSS, regardless of opioid experience. Pain and sedation will be recorded multiple times during the scheduled procedure. If rescue medication is needed during the procedure, local anesthetic standard of care for the procedure will be administered and recorded in the study record. Efficacy and safety/tolerability of fentanyl sublingual spray will be evaluated among and between the treatment groups.

Study Timeline

• Study First Submitted: 2014-05-12
• Study First Submitted QC: 2014-05-12
• Study First Posted: 2014-05-14
• Study Start: 2017-12-30
• Status Verified: 2018-01
• Primary Completion: 2018-01
• Study Completion: 2018-01
• Last Update Submitted: 2018-01-02
• Last Update Posted: 2018-01-04

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Has scheduled an interventional procedure for treatment of pain without sedation
• Has cleared pre-operative assessment
• Is able to read or understand informed consent form, and gives consent to participate in the study

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Exclusion Criteria

• Is taking any form of fentanyl
• Has oral pathology that would prevent effective absorption of study medication
• Was treated with an investigational drug within protocol-specified parameters
• Has signs, symptoms or history of any condition that, per protocol or in the opinion of the investigator, might compromise: 1) the safety or well-being of the participant or study staff, 2) the safety or well-being of the participant's offspring (such as through pregnancy or breast-feeding), 3) the analysis of results

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ON FSS 200 µg	Fentanyl Sublingual Spray (FSS)	Participants classified as opioid-naïve (ON), randomized to receive one dose of fentanyl sublingual spray (FSS) 10 minutes before treatment procedure, and further randomized to a dose of 200 µg
OE FSS 400 µg	Fentanyl Sublingual Spray (FSS)	Participants classified as opioid-experienced (OE), randomized to receive one dose of fentanyl sublingual spray (FSS) 10 minutes before treatment procedure, at a dose of 400 µg
OE PSS	Placebo Sublingual Spray (PSS)	Participants classified as opioid-experienced (OE) and randomized to receive one dose of matching placebo sublingual spray (PSS) 10 minutes before treatment procedure
ON FSS 100 µg	Fentanyl Sublingual Spray (FSS)	Participants classified as opioid-naïve (ON), randomized to receive one dose of fentanyl sublingual spray (FSS) 10 minutes before treatment procedure, and further randomized to a dose of 100 µg
ON PSS	Placebo Sublingual Spray (PSS)	Participants classified as opioid-naïve (ON) and randomized to receive one dose of matching placebo sublingual spray (PSS) 10 minutes before treatment procedure

Primary Outcome Measures

Name	Time	Method
Pain scored on a scale from 0 to 10, where 0 = no pain and 10 = the most intense pain imaginable	within 24 hours

Secondary Outcome Measures

Name	Time	Method
Sedation scored on a scale from 0 to 4, where 0 = awake/alert and 4 = unarousable	within 24 hours