Study of Olfaction / Vision Interactions in Expert and Novice Populations

Not Applicable

• Conditions: Healthy
• Interventions: Other: Odor presentation (for participants' perception); Other: Image presentation (for participants' perception)

• Registration Number: NCT03058172
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The aim of this research project is to better understand the reciprocal influence of visual and olfactory systems on cerebral activity evoked by odors and visual stimuli. Given the importance of olfacto-visual learning in expert situations, the degree of expertise in olfaction will also be considered. In addition, the investigators will try to better understand the differences between expert and non-expert populations in olfaction through different levels of approach: sensory, genetic and cerebral. To achieve this, the investigators will use psychophysical tests, genetic analyzes and a non-invasive technique, functional magnetic resonance imaging (fMRI) to measure the brain activity of human subjects - novices or experts in olfaction - in response to different visual and olfactory stimuli.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-04-15
• Study First Submitted: 2017-02-08
• Study First Submitted QC: 2017-02-15
• Study First Posted: 2017-02-20
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-20
• Last Update Posted: 2021-07-21
• Primary Completion: 2022-03-15
• Study Completion: 2022-04-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• healthy volunteers
• men and women, aged 18-85 years old
• subjects with social security cover
• expertise in olfaction for half of the subjects (60)

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Exclusion Criteria

• subjects younger than 18 and older than 85
• subjects with contraindications to fMRI, i.e. with pacemaker / insulin pump / metal prosthesis / intracerebral clip / neurosensory stimulator / implantable defibrillator / cochlear implants / ferromagnetic ocular or cerebral foreign body close to the nerve structures / ventriculoperitoneal neurosurgical bypass valves / braces and other non-removable metallic dental device / claustrophobic, non-cooperating or agitated subjects.
• pregnant or breastfeeding women
• subjects with known olfactory disorder
• subjects with known neurological disorder

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Odors (food and non-food)	Odor presentation (for participants' perception)	Odorants diluted in mineral oil.
Pictures (food and non-food)	Image presentation (for participants' perception)	Pictures of objects or scenes.

Primary Outcome Measures

Name	Time	Method
Brain activity	During the 2-hour testing session (one session per participant)	fMRI 3T scanner in CERMEP imaging center (Bron - see web link at the end of the document), allowing anatomical measures, connectivity between olfactory and other regions (DTI), activation pattern in olfactory and visual areas.

Secondary Outcome Measures

Name	Time	Method
Response times	During the 2-hour testing session (one session per participant)	Response time to the olfactory/visual stimulus in millisecond
Genotyping	Sampling during the 2-hour testing session (one session per participant), analyses within 6 years after sampling	Genotyping from saliva samples by AMIS laboratory or a genotyping platform in Toulouse or Evry (see web links at the end of the document)
Olfactory abilities	During the 2-hour testing session (one session per participant)	Threshold detection, discrimination between odorants and odor identification, measured with standardized olfactory tests
Perception	During the 2-hour testing session (one session per participant)	Assesment of the perceptual profile of the stimulus on visual analogue scale (verbal report of how the olfactory/visual stimulus is perceived).

Trial Locations

Locations (1)

Infirmerie Protestante; 🇫🇷 Caluire et Cuire, France