The value of ultrasound compared to magnetic resonance imaging in haemophilic arthropathy
Completed
- Conditions
- Haemophilic arthropathy1000533010064477
- Registration Number
- NL-OMON40804
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 26
Inclusion Criteria
• Clinical and radiological absent or minimal arthropathy
• Participation in MRI study by Den Uijl:
- MRI assessment of both knees and ankles by the standardized MRI protocol described by Den Uijl in 2009/2010
- Severe (<1% FVIII/IX activity) or moderate haemophilia (1-5% FVIII/IX activity)
Exclusion Criteria
• History of inhibitors
• Contra indication for MRI
• Exclusion of joints in case of a severe joint injury, joint surgery, or development of a target joint since initial MRI assessment in 2009/2010
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Research question 1: Ultrasound and MRI scores for synovial hypertrophy<br /><br>according to the HEAD-US score and the additive IPSG MRI score respectively. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Research question 2a: MRI scores for synovial hypertrophy, haemosiderin, and<br /><br>osteochondral defects on the initial MRI, and MRI scores for osteochondral<br /><br>defects at re-examination.<br /><br>Research question 2b: MRI scores for synovial hypertrophy at the initial MRI,<br /><br>and MRI scores for synovial hypertrophy at re-examination.<br /><br>Determinants of interest are: Number of joint bleeds between MRI examinations<br /><br>specified per joint, age, history of joint injuries, and Body Mass Index (BMI).</p><br>