Parkinson´s Disease, Aerobic Exercise and Photobiomodulation

Not Applicable

Completed

• Conditions: Parkinson Disease
• Interventions: Other: Aerobic training; Other: Photobiomodulation

• Registration Number: NCT05152706
• Lead Sponsor: University of Oviedo

Brief Summary

The aim of the present study was to assess the effects of a combined therapy of aerobic exercise and transcranial photobiomodulation upon the cardinal motor sympomts of Parkinson´s disease of a group of Parkinson´s disease patients. It was hypothesized that aerobic exercise and transcranial photobiomodulation would yield significant benefits in the cardinal motor sympomts of the illness.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-10
• Study First Submitted: 2021-11-28
• Study First Submitted QC: 2021-11-28
• Study First Posted: 2021-12-10
• Primary Completion: 2024-06-30
• Study Completion: 2024-06-30
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-03
• Last Update Posted: 2024-12-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• Diagnosis with idiopathic PD and rated 1-2 on the Hoehn and Yahr Scale.
• No type of dementia as assessed by the mini-mental state examination.
• Able to stand for 2 min without assistance.
• Able to walk 10 m without assistance.

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Exclusion Criteria

• Individuals were excluded if they suffered a neurological disease other than PD, if the subject has an implant of any kind in the head (e.g., stent, clipped aneurysm, embolized arteriovenous malformation, implantable shunt - Hakim valve) or if they did not meet the eligibility criteria.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Intervention aerobic and photobiomodulation (IAER+PBM9	Aerobic training	Patients assigned to the IAER+PBM participated in the aerobic exercise therapy and the PBM one at the same time, during six months.
Intervention aerobic (IAER)	Aerobic training	Patients assigned to the IAER participated in fourty-eigth aerobic exercise therapy sessions over the course of six months.
Intervention photobiomodulation (IPBM)	Photobiomodulation	Patients assigned to the IPBM participated in fourty-eigth transcraneal photobiomodulation (PBM) theraphy sessions, using a therapeutic laser console, over the course of six months.
Intervention aerobic and photobiomodulation (IAER+PBM9	Photobiomodulation	Patients assigned to the IAER+PBM participated in the aerobic exercise therapy and the PBM one at the same time, during six months.

Primary Outcome Measures

Name	Time	Method
MDS-UPDRS	6 months	The motor portion of the Movement Disorder Society-Unified Parkinson´s (MDS-UPDRS, the minimum and maximum values are 0 and 72, respectively and the higher score, the worse patient condition)

Secondary Outcome Measures

Name	Time	Method
Static posturography	6 months	The centre of pressure (CoP) parameters (these CoP parameters; Length, in mm, Area in mm2 and Speed, Xspeed and Yspeed in m/s will be combined to report the static posturography)
TMWT	6 months	10 meters walking test (speed in seconds)
Grip strength	6 months	Grip strength in kg
DASH	6 months	The disabilities of the arm, shoulder and hand (DASH, the minimun and maximum values are 0 and 190, respectively and the higher score, the worse patient condition)
TUG	6 months	Time up Go Test (speed in seconds)

Trial Locations

Locations (1)

Department of Physical Education and Sport, University of León; 🇪🇸 León, Castilla y León, Spain