Evaluation of Efficacy, Safety and Tolerability of Targretin Capsules in Patients With Advanced or Metastatic Non-small Cell Lung Cancer
- Conditions
- Non-small Cell Lung Cancer
- Registration Number
- NCT00050973
- Lead Sponsor
- Eisai Inc.
- Brief Summary
This study evaluates the use of Targretin capsules (bexarotene) in combination with standard chemotherapy for the treatment of metastatic Non-Small Cell Lung Cancer (NSCLC) in patients who have not yet received chemotherapy for their lung cancer.
- Detailed Description
This study evaluates the use of Targretin capsules (bexarotene) in combination with Cisplatin and Vinorelbine for the treatment of metastatic non-small cell lung cancer in patients who have not yet received chemotherapy for their lung cancer. Every patient receives a platinum-containing chemotherapy every four weeks for at least four chemotherapy cycles (approximately four months). Half of the patients are randomly assigned to receive Targretin capsules once daily in addition to the chemotherapy. The other half is randomized to receive a standard platinum-containing chemotherapy without Targretin capsules.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 623
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (77)
Guys & St. Thomas' Cancer Centre
🇬🇧London, England, United Kingdom
Cancer Care Manitoba
🇨🇦Winnepeg, Manitoba, Canada
University Oncology & Hematology Associates
🇺🇸Chattanooga, Tennessee, United States
Veterans Affairs Medical Center
🇺🇸Miami, Florida, United States
Desert Hematology-Oncology Medical Group, Inc.
🇺🇸Rancho Mirage, California, United States
SUNY Downstate Medical Center
🇺🇸Brooklyn, New York, United States
Port Macquarie Base Hospital
🇦🇺Port Macquarie, New South Wales, Australia
Northwest Medical Specialists
🇺🇸Arlington Heights, Illinois, United States
VA Western New York Health Care System
🇺🇸Buffalo, New York, United States
Hematology-Oncology Associates
🇺🇸Toledo, Ohio, United States
Capitol Comprehensive Cancer Care Clinic
🇺🇸Jefferson City, Missouri, United States
Regionalne Centrum Onkologii
🇵🇱Bialystok, Poland
Wielkopolskie Centrum Chorob Pluc I Gruzlicy
🇵🇱Poznan, Poland
Instytut Gruzlicy i Chorob Pluc
🇵🇱Warsaw, Poland
Arkhangelsk Regional Oncology Center
🇷🇺Arkhangelsk, Russian Federation
City Oncology Center
🇷🇺St. Petersburg, Russian Federation
Arroyo Research Inc.
🇺🇸Pasadena, California, United States
University of Florida
🇺🇸Gainsville, Florida, United States
Jayne Gurtler, M.D., APMC
🇺🇸Metairie, Louisiana, United States
Tariq Mahmood
🇺🇸MIdwest City, Oklahoma, United States
Barzilai Medical Centre
🇮🇱Ashkelon, Israel
Central Clinical Hospital n.a. Semashko
🇷🇺Moscow, Russian Federation
Brookwood Medical Center
🇺🇸Birmingham, Alabama, United States
City Oncology Hospital #62
🇷🇺Moscow, Russian Federation
St. Petersburg Pavlov State Medical University
🇷🇺St. Petersburg, Russian Federation
Southern Arizona VA Healthcare System
🇺🇸Tucson, Arizona, United States
Southern Medical Daycare Centre
🇦🇺Wollongong, New South Wales, Australia
Research Institute of Oncology n.a. Petrov
🇷🇺St. Petersburg, Russian Federation
Bristol Hematology and Oncology Centre
🇬🇧Bristol, England, United Kingdom
Chelsea & Westminster Hospital
🇬🇧London, England, United Kingdom
Marshfield Medical Research Foundation
🇺🇸Marshfield, Wisconsin, United States
Pneumologicka klinika 1. LF UK
🇨🇿Praha-6-Veleslavin, Czech Republic
2nd Pulmonary Clinic of G. Papanikolaou Hospital
🇬🇷Exochi, Thessaloniki, Greece
Hadassah Medical Center
🇮🇱Jerusalem, Israel
Assaf Harofeh Medical Center
🇮🇱Zerifin, Israel
Burnside War Memorial Hospital
🇦🇺Toorak Gardens, South Australia, Australia
Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
Klinika pneumologie a hrudni chirurgie 3.LF
🇨🇿Praha-8, Czech Republic
Institut Jean Godinot
🇫🇷Reims, Cedex, France
University Hospital of Alexandroupolis
🇬🇷Dragana, Alexandroupolis, Greece
Meir Hospital
🇮🇱Kfar Sava, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
St. Joseph Mercy Oakland Hospital
🇺🇸Pontiac, Michigan, United States
Queen Elizabeth Hospital
🇦🇺Woodville, South Australia, Australia
Fovarosi Onkormanyzat Uzsoki utcai, Korhaza
ðŸ‡ðŸ‡ºBudapest, Hungary
Koranyi National Institute for Pulmonology
ðŸ‡ðŸ‡ºBudapest, Hungary
Centre Hospitalier General de Belfort
🇫🇷Belfort, Cedex, France
Centre Hospitalier Francois Maillot
🇫🇷Briey, Cedex, France
University General Hospital of Heraklion
🇬🇷Heraklion, Crete, Greece
1st Pulmonary Clinic of G. Papanikolaou Hospital
🇬🇷Exochi, Thessaloniki, Greece
6th Pneumonology Department, Sotiria Hospital for Diseases of the Chest
🇬🇷Athens, Greece
University Hospital of Patras
🇬🇷Rio, Greece
Research Institute of Oncology n.a. Hertzen
🇷🇺Moscow, Russian Federation
7th Pneumonology Clinic, Sotiria Hospital for Diseases of the Chest
🇬🇷Athens, Greece
Csongrad Megyei Onkormanyzat Mellkasi
ðŸ‡ðŸ‡ºDeszk, Hungary
Akademii Medycznej w Gdansku
🇵🇱Gdansk, Poland
QEII Health Sciences Center
🇨🇦Halifax, Nova Scotia, Canada
Louisiana State University Health Science Center
🇺🇸New Orleans, Louisiana, United States
New Hope Cancer Center
🇺🇸Hudson, Florida, United States
Bay Area Cancer Consultants
🇺🇸Palm Harbor, Florida, United States
Medical Associates Health Centers
🇺🇸Menomonee Falls, Wisconsin, United States
Canberra Hospital
🇦🇺Garran, Australian Capital Territory, Australia
Royal Hobart Hospital
🇦🇺Hobart, Tasmania, Australia
Semmelweis University Department of Pulmonology
ðŸ‡ðŸ‡ºBudapest, Hungary
Ottawa Regional Cancer Centre
🇨🇦Ottawa, Ontario, Canada
Nemocnice odd. Onkologie
🇨🇿Ceske Budejovice, Czech Republic
Centre Hospitalier Intercommunal de la Haute-Saone
🇫🇷Vesoul, Cedex, France
Tel-Aviv Sovrasky Medical Center
🇮🇱Tel Aviv, Israel
Centrum Onkologii Instytut im. M. Sklodowskiej-Curie
🇵🇱Krakow, Poland
Border Medical Oncology
🇦🇺Wodonga, Victoria, Australia
City Oncology Clinical Center
🇷🇺Moscow, Russian Federation
Russian Oncology Research Center n.a. Blokhin
🇷🇺Moscow, Russian Federation
Leicester Royal Infirmary
🇬🇧Leicester, England, United Kingdom
Sheba Medical Center
🇮🇱Tel Hashomer, Israel
Aberdeen Royal Infirmary
🇬🇧Foresterhill, Aberdeen, United Kingdom
Tom Baker Cancer Centre
🇨🇦Calgary, Alberta, Canada
University of Edinburgh
🇬🇧Edinburgh, Scotland, United Kingdom