This is a study taken to see the effects of tab tizanidine which is a sedative on propofol consumption during general anaesthesia.
Phase 2
Not yet recruiting
- Conditions
- Health Condition 1: K55-K64- Other diseases of intestines
- Registration Number
- CTRI/2020/03/024250
- Lead Sponsor
- Bangalore medical College and research institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Patient who are willing to give informed consent.
2) Patients of age 18-60 years of either sex.
3) ASA grade I and II.
4) Patients scheduled for elective surgery lasting for 90-120 mins under general anaesthesia
Exclusion Criteria
1.Patients who are not willing to give informed consent
2.SA grade III and above.
3.Age <18 and >60 years.
4.Patients with hemodynamic instability.
5.Presence of systemic disorders involving respiratory, cardiac, renal or hepatic system
6.Patients with anticipated difficult airway.
7.Pregnant women.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dose of propofol required for induction under entropy guidanceTimepoint: Till entropy reads 40-60 following induction
- Secondary Outcome Measures
Name Time Method Hemodynamic stress response to laryngoscopy and intubationTimepoint: Till 10 mins post intubation
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms explain tizanidine's effect on propofol requirements during anesthesia?
How does tizanidine compare to other premedication agents in reducing propofol consumption for anesthesia induction?
Are there specific biomarkers that predict patient response to tizanidine as a premedication in ENTROPY guided anesthesia?
What are the potential adverse events associated with tizanidine premedication in gastrointestinal disease patients undergoing anesthesia?
What combination therapies or alternative drugs show similar effects to tizanidine in modulating anesthetic agent requirements for patients with intestinal disorders?