A RANDOMISED CONTROL STUDY TO EVALUATE THE ROLE OF PREOPERATIVE ORAL PARACETAMOL, ETORICOXIB, PREGABALIN, DEXAMETHASONE ON POSTOPERATIVE AND PERSISTENT PAIN AFTER MASTECTOMY

Parmanand N Jain0 个研究点目标入组 82 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1.ASA I/ ASA II patients
•2.Post chemotherapy patients, posted for 3.unilateral non-reconstructive breast surgeries like modified radical mastectomy,simple mastectomy with axillary clearance, breast conservation surgery.
•4.Age group of 20-65 yrs

•1.Diabetic patients
•2. ASA- III, ASA- IV patients
•3. Below 20 yrs& Beyond 70yrs of age
•4. Patients having preoperative pain
•5. Patients undergoing reconstructive surgeries like latisimusdorsi flap, deep inferior epigastric free flap, gracilis flap
•6. Patients with deranged liver function tests or kidney function tests
•7. Hypersensitivity to paracetamol/etoricoxib/ pregabalin/ dexamethasone,Pregnant, nursing or geriatric patients,Active peptic ulceration or active gastro-intestinal (GI) bleeding,Patients taking aspirin tablets on a daily basis
•8. Patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneuroticoedema, urticaria, or allergic-type reactions after taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors,Inflammatory bowel disease,Congestive heart failure (NYHA II-IV),Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
•9. Patients with psychological disorders,Uncontrolled infections, Systemic fungal infection,Concurrent treatment with live virus vaccines,A history of epilepsy,Alcohol, drug or both abuse,A daily intake of analgesics, except for non-steroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2 inhibitors or paracetamol
•10. Patients enrolled for the EXERCISE study and VGSC study under DMG Breast Unit, Tata Memorial Centre.

发起方

Parmanand N Jain