The Effect of Dietary Intervention on Endothelial Glycocalyx Integrity and Microvascular Perfusion in Patients With Psoriatic Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Psoriasis
- Sponsor
- University of Athens
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Endocalyx effects on endothelial glycocalyx thickness
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis. The investigators will study the effect of Endocalyx on endothelial, vascular and left ventricular myocardial function in patients with psoriatic disease.
Detailed Description
Sixty patients with psoriatic disease, who are referred to the outpatient psoriasis clinic of the Attikon University Hospital, will be randomized to receive food supplement Endocalyx (4 capsules per day) (n=30) or placebo (n=30) for 4 consecutive months.
Investigators
Ignatios Ikonomidis
Professor of Cardiology
University of Athens
Eligibility Criteria
Inclusion Criteria
- •Caucasian patients with psoriatic disease (plaque-type psoriasis or psoriatic arthritis)
- •Body mass index ≥18.5 Kg/m2
- •If female, patients must be non-pregnant and non-breastfeeding
Exclusion Criteria
- •History of acute coronary syndrome. Coronary artery disease will be excluded by a clinical history, examination and electrocardiogram.
- •Moderate or severe valve disease
- •Primary cardiomyopathies
- •Chronic obstructive pulmonary disease
- •Chronic kidney disease
- •Liver failure
- •Malignancies
Outcomes
Primary Outcomes
Endocalyx effects on endothelial glycocalyx thickness
Time Frame: four months
Endocalyx effects on endothelial glycocalyx thickness as assessed by perfused boundary region (PBR, micrometers) of the sublingual arterial microvessels using Sidestream Dark Field (SDF) imaging.
Secondary Outcomes
- Endocalyx effects on coronary microcirculation(four months)
- Endocalyx effects on arterial stiffness(four months)
- Endocalyx effects on left ventricular myocardial function(four months)