The Effect of Dietary Glycocalyx Precursor Supplementation on Endothelial Function, on Markers of Vascular Function and on Cardiac Performance in Patients With COVID-19 Infection.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID-19
- Sponsor
- University of Athens
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Endocalyx effects on endothelial glycocalyx thickness
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis. The investigators will study the effect of Endocalyx on endothelial, vascular and left ventricular myocardial function in patients with COVID-19 infection.
Detailed Description
Sixty patients who have been hospitalized due to COVID-19 infection will be randomized to receive food supplement Endocalyx (4 capsules per day) (n=30) or placebo (n=30) for 4 consecutive months.
Investigators
Ignatios Ikonomidis
Professor of Cardiology
University of Athens
Eligibility Criteria
Inclusion Criteria
- •caucasian patients
- •hospitalization for COVID-19 infection
- •diagnosis of COVID-19 proven by PCR
Exclusion Criteria
- •Pregnancy and breastfeeding
- •Foreseen inability to attend scheduled visits
- •History of acute coronary syndrome. Coronary artery disease will be excluded by a clinical history, examination and electrocardiogram.
- •Moderate or severe valve disease
- •Primary cardiomyopathies
- •Chronic obstructive pulmonary disease
- •Chronic kidney disease (estimated glomerular filtration rate \[eGFR\] ≤60 ml/min/1.73 m2)
- •Liver failure
- •Malignancies
Outcomes
Primary Outcomes
Endocalyx effects on endothelial glycocalyx thickness
Time Frame: four months
Endocalyx effects on endothelial glycocalyx thickness as assessed by perfused boundary region (PBR, micrometers) of the sublingual arterial microvessels using Sidestream Dark Field (SDF) imaging
Secondary Outcomes
- Endocalyx effects on arterial stiffness(four months)
- Endocalyx effects on coronary microcirculation(four months)
- Endocalyx effects on left ventricular myocardial function(four months)