To Evaluate the Efficacy of Sugammadex in Reversing the effect of a Muscle Relaxant in Patients Undergoing Major Upper Abdominal Surgery: An Observational Study

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/07/055172
• Lead Sponsor: Dr. Ram Manohar Lohia Institute of Medical Sciences

Brief Summary

During general anesthesia muscle relaxants are given to faciliotate endotracheal intubation and for optimum surgical conditions. A complication may be post operative residual blockade during a prolonged surgical procedure. Intraoperatively Neuromuscular monitoring can be used to allow proper administration of the relaxant to decrease the incidence of post operative residual curarization. After the completion of the surgery we use a reversal agent as in this case, Sugammadex which has showed decreased incidence of the post operative complications related to residual blockade. Diaphragm Ultrasound (Thickening fractioning) and Neuromuscular monitoring (Train of Four ratio) will be the primary modalities we use to evaluate the efficacy of Sugammadex against the traditionally used reversal Neostigmine.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-25
• Last Update Posted: 2023-12-07

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

ASA 1 and 2 Patients posted for major upper abdominal surgery.

Exclusion Criteria

Refusal to consent ASA 3, 4 and Emergency cases Patients with preoperative respiratory involvement BMI >30.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the time from administration of Sugammadex till extubation on the basis of Train of Four ratio 0.9	After administration of Reversal agent

Secondary Outcome Measures

Name	Time	Method
To detremine the risk of post operative residual paralysis using diaphragm ultrasound	Preoperative baseline

Trial Locations

Locations (1)

Dr. Ram Manohar Lohia Institute of Medical Sciences; 🇮🇳 Lucknow, UTTAR PRADESH, India

Dr. Ram Manohar Lohia Institute of Medical Sciences

🇮🇳Lucknow, UTTAR PRADESH, India

Dr Shilpi Misra

Principal investigator

9839932239

drshilpi1980@gmail.com