跳至主要内容
临床试验/CTRI/2023/07/055172
CTRI/2023/07/055172尚未招募不适用

Evaluation of Efficacy of Sugammadex for Reversal of Neuromuscular Blockade in Patients Undergoing Major Upper Abdominal Surgery: An Observational Study

Dr. Ram Manohar Lohia Institute of Medical Sciences1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2023年7月25日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
50
试验地点
1
主要终点
To determine the time from administration of Sugammadex till extubation on the basis of Train of Four ratio 0.9

研究概览

简要总结

During general anesthesia muscle relaxants are given to faciliotate endotracheal intubation and for optimum surgical conditions. A complication may be post operative residual blockade during a prolonged surgical procedure. Intraoperatively Neuromuscular monitoring can be used to allow proper administration of the relaxant to decrease the incidence of post operative residual curarization. After the completion of the surgery we use a reversal agent as in this case, Sugammadex which has showed decreased incidence of the post operative complications related to residual blockade. Diaphragm Ultrasound (Thickening fractioning) and Neuromuscular monitoring (Train of Four ratio) will be the primary modalities we use to evaluate the efficacy of Sugammadex against the traditionally used reversal Neostigmine.

研究设计

研究类型
Interventional
分配方式
Not Applicable
盲法
Participant Blinded

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • ASA 1 and 2 Patients posted for major upper abdominal surgery.

排除标准

  • Refusal to consent ASA 3, 4 and Emergency cases Patients with preoperative respiratory involvement BMI >30.

结局指标

主要结局

To determine the time from administration of Sugammadex till extubation on the basis of Train of Four ratio 0.9

时间窗: After administration of Reversal agent

次要结局

  • To detremine the risk of post operative residual paralysis using diaphragm ultrasound(Preoperative baseline)

研究者

发起方
Dr. Ram Manohar Lohia Institute of Medical Sciences
申办方类型
Government medical college

研究点 (1)

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