Skip to main content
Clinical Trials/NCT03906838
NCT03906838
Withdrawn
Early Phase 1

Does Regional Anesthesia Reduce Postoperative Opioid Consumption in Subjects Undergoing Fibula Free Flap Reconstruction of the Head and Neck: A Prospective Trial

University of Florida1 site in 1 countryJanuary 1, 2020

Overview

Phase
Early Phase 1
Intervention
Ropivacaine injection
Conditions
Anesthesia, Local
Sponsor
University of Florida
Locations
1
Primary Endpoint
Opioid consumption
Status
Withdrawn
Last Updated
6 years ago

Overview

Brief Summary

Despite many recent advances in pain management, post-operative pain is widely considered to be poorly managed. Furthermore, the mainstay of current pain management is opioids, for which there is strong evidence of ill effects and long-term potential for addiction. There are many studies demonstrating that perineural regional anesthesia can be superior to intravenous opioid analgesia, and that the technique is safe. By using temporary implanted catheters, this method can now deliver prolonged analgesia, thus reducing the need for opioids in the postoperative period. Regional anesthesia is a proven technique and used daily by anesthesiologists, and it is also the first choice for hip and knee replacement surgery for orthopedic surgeons. Patients undergoing head and neck reconstruction with the use of free tissue transfer experience a significant amount of post-operative pain due to the complexity of the surgery, the presence of a head and neck surgical site as well as a secondary donor site, and existing co-morbidities, most commonly malignancy, that also cause significant pain. These patients often require opioids for pain control throughout the hospital stay, and are almost always discharged home with additional opioids. By utilizing regional anesthesia blocks at the donor sites, the investigators can potentially reduce post-operative pain while also reducing the use of opioids.

Registry
clinicaltrials.gov
Start Date
January 1, 2020
End Date
November 30, 2020
Last Updated
6 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Subjects undergoing microvascular fibula free flap reconstruction of the head and neck
  • Subjects undergoing primary or secondary reconstruction

Exclusion Criteria

  • Subjects needing elevation of care to the intensive care unit due to remaining intubated for extended period of time or other complications during the peri or post operative period
  • Subjects with surgical complications requiring significant alteration of the treatment plan
  • o Subjects requiring a return to the operating room during admission will be excluded, unless it is for a procedure not related to the original surgery occurring after post op day 3, such as a gastrostomy tube or long term IV access.
  • Subjects with true allergies to the study drugs
  • Subjects undergoing reconstruction with more than 1 free flap, or with the use of any additional regional flaps
  • History of substance dependence or enrollment in a pain management program
  • Any subject currently enrolled in pain management, or currently taking long acting opioids such as methadone or oxycontin.
  • Subjects who do not stay in the hospital for at least 4 days post operatively
  • Subjects requiring anticoagulation will not require modifications prior to receiving regional anesthesia.
  • Inability to properly place catheter or administer the regional anesthesia

Arms & Interventions

Regional Nerve Block

Subjects in the regional anesthesia cohort will have a regional anesthesia block and/or catheter placement administered according to current hospital policies and our established standard of care.

Intervention: Ropivacaine injection

Outcomes

Primary Outcomes

Opioid consumption

Time Frame: 72 hours (3 days) post-operatively

Defined by the research team as the subjects' morphine equivalent dose at 72 hours (3 days) post-operatively. The postoperative period commences at extubation.

Study Sites (1)

Loading locations...

Similar Trials