Metabolism of the Insecticide Permethrin

Not Applicable

Completed

• Conditions: Pharmacokinetics; Metabolism

• Registration Number: NCT00572884
• Lead Sponsor: University of California, Davis

Brief Summary

Military personnel are exposed to the insecticide permethrin when using the DOD Insect Repellent System. A urinary metabolite of permethrin that is in high abundance and is relatively stable may be an ideal biomarker of exposure to this pesticide. Monitoring such a biomarker can prevent over-exposure. The objectives are to identify the most abundant human urinary metabolite following dermal exposure; to utilize this information to develop rapid laboratory-based and field portable methods to monitor the degree of an individual's exposure to permethrin.

Detailed Description

Permethrin is applied to the forearm of the subject and remains for 8 hours. The exposed area is then washed with soap and water several times. 24 hour urine samples are collected at daily intervals for 192 hours. Blood and saliva samples are taken at pre-dose, 1, 3, 6, 9 12, 24, 48, 72, 96, 120, 144, 168 and 192 hours. Subjects must return to the clinic daily to drop off urine collections and have blood and saliva samples taken.

Study Timeline

• Study Start: 2006-02
• Study Completion: 2007-11
• Status Verified: 2007-12
• Study First Submitted: 2007-12-11
• Study First Submitted QC: 2007-12-11
• Last Update Submitted: 2007-12-11
• Study First Posted: 2007-12-13
• Last Update Posted: 2007-12-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• self-report healthy adult men and premenopausal women

Exclusion Criteria

• unusual alcohol, drug, cigarette use for last 3 years
• unusual exercise program for last 3 years
• under the care of a physician for a disease
• participated in any radioactive drug study
• pregnant
• lactating
• people who rely more on their arm due to illness or injury
• people with neurological or musculoskeletal diseases
• use of permethrin in the last 6 months
• people who apply pesticides as their primary occupation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Concentration of individual metabolites in urine	192 hours

Secondary Outcome Measures

Name	Time	Method
total carbon-14 in serum	192 hours
Total carbon-14 in saliva	192 hours
Total carbon-14 in urine samples	192 hours

Trial Locations

Locations (1)

CTSC Research Center; 🇺🇸 Mather, California, United States