The changing over time of ascorbic acid after chemotherapy and the correlation between ascorbic acid and the recovery of the immune cells after chemotherapy in patients receiving intensive clinical chemotherapy for acute leukemia and high dose chemotherapy with autologous stem cell rescue and in outpatients receiving relatively mild chemotherapy for lung cancer and colon cancer.
Completed
- Conditions
- malignancies cancer1002432410027656
- Registration Number
- NL-OMON47053
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Trial ended prematurely
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 35
Inclusion Criteria
- 18 years or older
- written informed consent
- Require chemotherapy and will start this treatment in less than 1 month after registration for any of the following diseases:
• Acute leukemia or high risk myelodysplasia (RAEB2)
• Hematological disease requiring autologous stem cell transplantation after chemotherapy
- Or family member of a participant (without malignancy or chemotherapy)
Exclusion Criteria
- recent (<1 month ago) chemotherapy
- kidney failure requiring dialysis
- life expectancy < 1 month
- use of immunosuppressive medication other than chemotherapy and corticosteroids
- active vitamin C suppletion
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p> Influence of chemotherapy on AA levels in plasma and in leukocytes. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Relation between AA levels and immune cells.</p><br>